靶向钾通道和自噬以克服化疗耐药性。
Targeting potassium channels and autophagy to defeat chemoresistance.
作者信息
Petroni Giulia
机构信息
Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
出版信息
Mol Cell Oncol. 2020 Mar 30;7(3):1745038. doi: 10.1080/23723556.2020.1745038. eCollection 2020.
Abstract
Both autophagy and hERG1 potassium channels have been shown to promote tumor progression and resistance to treatment. Our findings indicate that the antibiotic clarithromycin can target hERG1 and modulate autophagy to promote the death of chemoresistant colorectal cancer cells. Thus, clarithromycin stands out as promising combinatorial partner to improve the efficacy of chemotherapy in patients with colorectal cancer.
摘要
自噬和hERG1钾通道均已被证明可促进肿瘤进展和治疗抗性。我们的研究结果表明，抗生素克拉霉素可靶向hERG1并调节自噬，以促进化疗耐药的结肠直肠癌细胞死亡。因此，克拉霉素作为一种有前景的联合用药伙伴脱颖而出，可提高结直肠癌患者的化疗疗效。
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Correction: Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K.更正：克拉霉素通过调节hERG1钾通道与PI3K的相互作用抑制结直肠癌中的自噬。
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本文引用的文献
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