Astete Carlos E, De Mel Judith U, Gupta Sudipta, Noh YeRim, Bleuel Markus, Schneider Gerald J, Sabliov Cristina M
Biological & Agricultural Engineering Department, Louisiana State University and LSU Ag Center, 149 E. B. Doran Bldg., Baton Rouge, Louisiana 70803, United States.
Department of Chemistry, Louisiana State University, Baton Rouge, 331 Chemistry and Materials Bldg, Louisiana 70803, United States.
ACS Omega. 2020 Apr 22;5(17):9892-9902. doi: 10.1021/acsomega.0c00168. eCollection 2020 May 5.
A lignin-graft-poly(lactic--glycolic) acid (PLGA) biopolymer was synthesized with two types of lignin (LGN), alkaline lignin (ALGN) and sodium lignosulfonate (SLGN), at different (A/S)LGN/PLGA ratios (1:2, 1:4, and 1:6 w/w). H NMR and Fourier-transform infrared spectroscopy (FT-IR) confirmed the conjugation of PLGA to LGN. The (A/S)LGN-graft-PLGA biopolymers were used to form nanodelivery systems suitable for entrapment and delivery of drugs for disease treatment. The LGN-graft-PLGA NPs were generally small (100-200 nm), increased in size with the amount of PLGA added, monodisperse, and negatively charged (-48 to -60 mV). Small-angle scattering data showed that particles feature a relatively smooth surface and a compact spherical structure with a distinct core and a shell. The core size and shell thickness varied with the LGN/PLGA ratio, and at a 1:6 ratio, the particles deviated from the core-shell structure to a complex internal structure. The newly developed (A/S)LGN-graft-PLGA NPs are proposed as a potential delivery system for applications in biopharmaceutical, food, and agricultural sectors.
使用两种木质素（LGN），即碱性木质素（ALGN）和木质素磺酸钠（SLGN），以不同的（A/S）LGN/PLGA比例（1:2、1:4和1:6 w/w）合成了木质素接枝聚（乳酸-乙醇酸）共聚物（PLGA）生物聚合物。核磁共振氢谱（¹H NMR）和傅里叶变换红外光谱（FT-IR）证实了PLGA与LGN的共轭。（A/S）LGN接枝PLGA生物聚合物被用于形成适合包封和递送药物以治疗疾病的纳米递送系统。LGN接枝PLGA纳米颗粒通常较小（100-200 nm），随着PLGA添加量的增加而增大，具有单分散性且带负电荷（-48至-60 mV）。小角散射数据表明，颗粒具有相对光滑的表面和紧凑的球形结构，有明显的核和壳。核尺寸和壳厚度随LGN/PLGA比例而变化，在1:6的比例下，颗粒从核壳结构偏离为复杂的内部结构。新开发的（A/S）LGN接枝PLGA纳米颗粒被提议作为一种潜在的递送系统，应用于生物制药、食品和农业领域。
