Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
Department of Obstetrics and Gynecology, General Hospital of Vienna, Vienna, Austria.
JAMA Netw Open. 2020 May 1;3(5):e204568. doi: 10.1001/jamanetworkopen.2020.4568.
In addition to treatment efficacy, evaluation of adverse effects and quality of life assessments have become increasingly relevant in oncology.
To evaluate the association of watching Disney movies during chemotherapy with emotional and social functioning and fatigue status.
DESIGN, SETTING, AND PARTICIPANTS: This randomized clinical trial was performed from December 2017 to December 2018 at a cancer referral center in Vienna, Austria. A consecutive sample of women with gynecologic cancers was recruited through July 2018. Inclusion criteria included age older than 18 years, written informed consent, and planned 6 cycles of chemotherapy with either carboplatin and paclitaxel or carboplatin and pegylated liposomal doxorubicin. Exclusion criteria were inadequate knowledge of the German language or receipt of other chemotherapy regimens. Data analysis was performed from February 2019 to April 2019.
Participants were either shown Disney movies or not during 6 cycles of chemotherapy. Before and after every cycle, they completed standardized questionnaires from the European Organisation for Research and Treatment of Cancer (EORTC).
Primary outcomes were change of quality of life, as defined by the EORTC Core-30 (version 3) questionnaire, and fatigue, as defined by the EORTC Quality of Life Questionnaire Fatigue, during 6 cycles of chemotherapy.
Fifty-six women entered the study, and 50 completed it, including 25 women in the Disney group (mean [SD] age, 59 [12] years) and 25 women in the control group (mean [SD] age, 62 [8] years). In the course of 6 cycles of chemotherapy, patients in the Disney group felt less tense and worried less than patients in the control group according to their responses to the questions about emotional functioning (mean [SD] score, 86.9 [14.3] vs 66.3 [27.2]; maximum test P = .02). Furthermore, watching Disney movies was associated with less encroachment on patients' family life and social activities, as evaluated by the social functioning questions (mean [SD] score, 86.1 [23.0] vs 63.6 [33.6]; maximum test P = .01). Moreover, this intervention led to fewer fatigue symptoms (mean [SD] score, 85.5 [13.6] vs 66.4 [22.5]; maximum test P = .01). Perceived global health status was not associated with watching Disney movies (mean [SD] score, 75.9 [17.6] vs 61.0 [25.1]; maximum test P = .16).
These findings suggest that watching Disney movies during chemotherapy may be associated with improvements in emotional functioning, social functioning, and fatigue status in patients with gynecologic cancers.
ClinicalTrials.gov Identifier: NCT03863912.
除了治疗效果外，对不良反应和生活质量评估的评估在肿瘤学中变得越来越重要。
评估在化疗期间观看迪士尼电影与情绪和社会功能以及疲劳状态的关联。
设计、设置和参与者：这项随机临床试验于 2017 年 12 月至 2018 年 12 月在奥地利维也纳的癌症转诊中心进行。通过 2018 年 7 月招募了患有妇科癌症的女性连续样本。纳入标准包括年龄大于 18 岁、书面知情同意书和计划接受 6 个周期的化疗，包括卡铂和紫杉醇或卡铂和聚乙二醇脂质体阿霉素。排除标准是对德语的了解不足或接受其他化疗方案。数据分析于 2019 年 2 月至 2019 年 4 月进行。
参与者在 6 个周期的化疗期间观看或不观看迪士尼电影。在每个周期前后，他们都使用欧洲癌症研究与治疗组织（EORTC）的标准化问卷完成了问卷。
主要结果是在 6 个化疗周期中，欧洲癌症研究与治疗组织核心 30 （第 3 版）问卷定义的生活质量变化，以及欧洲癌症研究与治疗组织生活质量问卷疲劳定义的疲劳变化。
共有 56 名女性进入研究，50 名女性完成了研究，其中 25 名女性在迪士尼组（平均[SD]年龄，59[12]岁），25 名女性在对照组（平均[SD]年龄，62[8]岁）。在 6 个化疗周期中，根据患者对情绪功能问题的回答，观看迪士尼电影的患者比对照组患者感觉紧张和焦虑程度较低（平均[SD]评分，86.9[14.3]与 66.3[27.2]；最大测试 P=0.02）。此外，观看迪士尼电影与患者家庭生活和社会活动的干扰较小有关，评估社会功能问题（平均[SD]评分，86.1[23.0]与 63.6[33.6]；最大测试 P=0.01）。此外，这种干预措施导致疲劳症状减少（平均[SD]评分，85.5[13.6]与 66.4[22.5]；最大测试 P=0.01）。观看迪士尼电影与感知的全球健康状况无关（平均[SD]评分，75.9[17.6]与 61.0[25.1]；最大测试 P=0.16）。
这些发现表明，在化疗期间观看迪士尼电影可能与妇科癌症患者的情绪功能、社会功能和疲劳状态的改善有关。
ClinicalTrials.gov 标识符：NCT03863912。
