Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Population Health Strategic Research Centre, School of Health and Social Development, Deakin University, Burwood, VIC, Australia.
Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Eur J Cancer. 2019 Jan;107:153-163. doi: 10.1016/j.ejca.2018.11.024. Epub 2018 Dec 19.
The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 health-related quality of life questionnaire is one of the most widely used cancer-specific health-related quality of life questionnaires worldwide. General population norm data can facilitate the interpretation of QLQ-C30 data obtained from cancer patients. This study aimed at systematically collecting norm data from the general population to develop European QLQ-C30 norm scores and to generate comparable norm data for individual countries in Europe and North America.
We collected QLQ-C30 data from the general population across 11 European Union (EU) countries, Russia, Turkey, Canada and United States (n ≥ 1000/country). Representative samples were stratified by sex and age groups (18-39, 40-49, 50-59, 60-69 and ≥ 70 years). After applying weights based on the United Nations population distribution statistics, we calculated QLQ-C30 domain scores to generate a 'European QLQ-C30 Norm' based on the EU countries. Further, we calculated QLQ-C30 norm scores for all 15 individual countries.
A total of 15,386 respondents completed the online survey. For the EU sample, most QLQ-C30 domains showed differences by sex/age, with men scoring somewhat better health than women, while age effects varied across domains. Substantially larger differences were seen in inter-country comparisons, with Austrian and Dutch respondents reporting consistently better health compared with British and Polish respondents.
This study is the first to systematically collect EORTC QLQ-C30 general population norm data across Europe and North America applying a consistent data collection method across 15 countries. These new norm data facilitate valid intra-country as well as inter-country comparisons and QLQ-C30 score interpretation.
欧洲癌症研究与治疗组织（EORTC）的 QLQ-C30 健康相关生活质量问卷是全球应用最广泛的癌症特异性健康相关生活质量问卷之一。一般人群的常模数据可以帮助解释从癌症患者中获得的 QLQ-C30 数据。本研究旨在系统地从一般人群中收集常模数据，制定欧洲版 QLQ-C30 常模评分，并为欧洲和北美各国产生可比的常模数据。
我们从 11 个欧盟国家、俄罗斯、土耳其、加拿大和美国的一般人群中收集了 QLQ-C30 数据（每个国家/地区的样本量≥1000）。代表性样本按性别和年龄组（18-39、40-49、50-59、60-69 和≥70 岁）分层。根据联合国人口分布统计数据应用权重后，我们计算了 QLQ-C30 各领域的评分，根据欧盟国家制定了“欧洲 QLQ-C30 常模”。此外，我们还计算了所有 15 个国家的 QLQ-C30 常模评分。
共有 15386 名受访者完成了在线调查。对于欧盟样本，大多数 QLQ-C30 领域的评分因性别/年龄而异，男性的健康状况略好于女性，而年龄的影响因领域而异。在国家间比较中，差异更大，奥地利和荷兰的受访者报告的健康状况明显好于英国和波兰的受访者。
本研究首次系统地收集了欧洲和北美的 EORTC QLQ-C30 一般人群常模数据，在 15 个国家应用了一致的数据收集方法。这些新的常模数据有助于在国内和国际上进行有效的比较以及对 QLQ-C30 评分的解释。
