保加利亚的糖尿病患者与非糖尿病患者的预期寿命和生存分析。
Life expectancy and survival analysis of patients with diabetes compared to the non diabetic population in Bulgaria.
机构信息
Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria.
Tulane University, New Orleans, Louisianna, United States of America.
出版信息
PLoS One. 2020 May 11;15(5):e0232815. doi: 10.1371/journal.pone.0232815. eCollection 2020.
AIMS
To evaluate the expected life expectancy in patients with diabetes in Bulgaria and to compare it to the expected life expectancy of the non-diabetic population in the country.
METHODS
It is a retrospective observational population study on individuals diagnosed with diabetes, compared to the non-diabetic population in Bulgaria for the period 2012-2015. Data from the national diabetes register and national statistical institute were used to construct life-tables with probability of survival with t-test and Chi Square test. Confounder analysis was done by age, sex, and type of diabetes. All-cause mortality and deaths in diabetic patients were analyzed. Kaplan-Meier survival curves were constructed for each age group and a log-rank analysis was conducted.
RESULTS
Average life expectancy in the non-diabetic population, patients with Type 1 DM and with Type 2 DM is 74.8; 70.96 and 75.19 years, respectively. For 2012-2015 the mortality in the non-diabetic population remained constant and lower (average-1.48%) compared to type-1 DM (5.25%) and Type-2 (4.27%). Relative risk of death in diabetics was higher overall (12%), after the age of 70 before which the relative risk was higher for the non-diabetic population. This was observed as a trend in all analyzed years.
CONCLUSION
Patients with type 2 DM have a longer life-expectancy than patients with type-1 DM and overall Diabetics life expectancy equals that of the non-diabetic population, which could suggest improved disease control and its associated complications in Bulgaria. Male diabetics show slightly longer life expectancy than their counterparts in the non-diabetic population, by a marginal gain of 0.6 years for the entire observed period. Life expectancy in diabetic women increased by 1.3 years, which was not observed in the non-diabetic population. Prevalence of diabetes was higher for women. Improved diabetes control may explain this gain in life; however other studies are needed to confirm this.
目的
评估保加利亚糖尿病患者的预期寿命，并将其与该国非糖尿病人群的预期寿命进行比较。
方法
这是一项回顾性观察性人群研究，对 2012 年至 2015 年期间被诊断为糖尿病的个体与保加利亚的非糖尿病人群进行了比较。使用国家糖尿病登记处和国家统计局的数据构建生存表，使用 t 检验和卡方检验比较生存率。通过年龄、性别和糖尿病类型进行混杂因素分析。分析所有原因死亡率和糖尿病患者的死亡情况。为每个年龄组构建 Kaplan-Meier 生存曲线，并进行对数秩检验。
结果
非糖尿病人群、1 型糖尿病患者和 2 型糖尿病患者的平均预期寿命分别为 74.8、70.96 和 75.19 岁。2012 年至 2015 年，非糖尿病人群的死亡率保持不变且较低（平均-1.48%），而 1 型糖尿病（5.25%）和 2 型糖尿病（4.27%）则较高。总体而言，糖尿病患者的死亡风险较高（12%），在 70 岁之前，非糖尿病人群的死亡风险更高。这一趋势在所有分析年份中均有所观察。
结论
2 型糖尿病患者的预期寿命长于 1 型糖尿病患者，总体而言，糖尿病患者的预期寿命与非糖尿病人群相当，这表明保加利亚的糖尿病控制及其相关并发症有所改善。男性糖尿病患者的预期寿命略长于非糖尿病人群，在整个观察期内，这一差距为 0.6 年。女性糖尿病患者的预期寿命增加了 1.3 年，而非糖尿病人群则没有观察到这一现象。女性糖尿病的患病率更高。改善糖尿病控制可能解释了这一预期寿命的增加；然而，还需要其他研究来证实这一点。
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