Department of Pathogenic Biology and Medical Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Clinical Medical College, Ningxia Medical University, Yinchuan, China.
J Med Food. 2020 Jul;23(7):699-710. doi: 10.1089/jmf.2019.4544. Epub 2020 May 11.
This study was designed to explore the impact of polysaccharide (LBP) on inflammation and gut microbiota in mice with allergic asthma. Mice were divided into four groups: control group, OVA (ovalbumin) group, Con+LBP group, OVA+LBP group. After 28 days of LBP intervention, mice were euthanized and associated indications were investigated. Histopathological examination demonstrated that LBP reduced lung injury. The results of our current study provide evidence that supplementation with LBP in asthmatic mice decreases , , , , and in plasma and bronchoalveolar lavage fluid (BALF). Sequencing and analysis of gut microbiota indicated that compared with the OVA group, and were increased, but , , , and were decreased in the OVA+LBP group. We also found that gut microbiota were related to inflammation-related factors. Therefore, we speculate that LBP may improve allergic asthma by altering gut microbiota and inhibiting inflammation in mice.
本研究旨在探讨多糖（LBP）对过敏性哮喘小鼠炎症和肠道微生物群的影响。将小鼠分为四组：对照组、OVA（卵清蛋白）组、Con+LBP 组、OVA+LBP 组。经过 28 天的 LBP 干预后，处死小鼠并检测相关指标。组织病理学检查表明，LBP 减轻了肺损伤。本研究结果提供了证据，表明在哮喘小鼠中补充 LBP 可降低血浆和支气管肺泡灌洗液（BALF）中的 、 、 、 和 。肠道微生物群的测序和分析表明，与 OVA 组相比，OVA+LBP 组中 、 增加，而 、 、 、 减少。我们还发现肠道微生物群与炎症相关因子有关。因此，我们推测 LBP 可能通过改变肠道微生物群和抑制小鼠炎症来改善过敏性哮喘。
