Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Department of Anatomical Sciences, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Cells Tissues Organs. 2020;209(1):43-53. doi: 10.1159/000507016. Epub 2020 May 11.
Peripheral nerve injury is a common clinical issue induced by trauma, tumor, and damage caused by treatment. Such factors create chemical and inflammatory alterations at the injury site, which increase nerve deterioration. Thus, minimizing these modifications can lead to nerve protection after injury. The present study sought to evaluate the possible improvement in nerve regeneration and enhancement of functional outcomes by cinnamaldehyde (Cin) administration following sciatic nerve crush in a rat model. Rats (n = 48) were distributed into 6 groups, including sham, injury, DMSO (vehicle group), and Cin groups (10, 30, and 90 mg/kg/day). Using small hemostatic forceps, crush injury was induced in the left sciatic nerve. Thereafter, Cin was administered for 28 successive days. Weekly records were taken for sciatic functional index (SFI) measurements. Further assessments including electrophysiological and histomorphometric evaluations, gastrocnemius muscle wet weight measurements, and estimation of the serum total oxidant status were performed. According to the results, Cin could accelerate sciatic nerve recovery after crush injury, and the dose of 30 mg/kg/day of Cin had better impacts on SFI recovery, muscle mass ratio, and myelin content. The current research demonstrated that Cin positively affects peripheral nerve restoration. Therefore, Cin therapy could be considered as a potential treatment method for peripheral nerve regeneration and its functional recovery. However, more investigations are required to further validate the study results and evaluate the optimal dose of Cin.
周围神经损伤是由创伤、肿瘤和治疗引起的损伤引起的常见临床问题。这些因素在损伤部位造成化学和炎症改变，增加神经恶化。因此，最大限度地减少这些改变可以在损伤后导致神经保护。本研究旨在评估肉桂醛（Cin）给药在大鼠坐骨神经挤压模型中对神经再生的可能改善作用和功能结果的增强作用。将大鼠（n = 48）分为 6 组，包括假手术组、损伤组、DMSO（载体组）和 Cin 组（10、30 和 90mg/kg/天）。使用小止血钳在左侧坐骨神经上造成挤压损伤。然后，连续 28 天给予 Cin。每周记录坐骨神经功能指数（SFI）测量值。进一步评估包括电生理学和组织形态计量学评估、腓肠肌湿重测量和血清总氧化状态估计。结果表明，Cin 可以加速挤压伤后坐骨神经的恢复，30mg/kg/天的 Cin 剂量对 SFI 恢复、肌肉质量比和髓鞘含量有更好的影响。本研究表明 Cin 对周围神经修复有积极影响。因此，Cin 治疗可被视为周围神经再生及其功能恢复的潜在治疗方法。然而，需要进一步的研究来进一步验证研究结果并评估 Cin 的最佳剂量。
