Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Biomed Res Int. 2020 Nov 14;2020:1034325. doi: 10.1155/2020/1034325. eCollection 2020.
Neurodegenerative diseases are devastating and incurable disorders characterized by neuronal dysfunction. The major focus of experimental and clinical studies are conducted on the effects of natural products and their active components on neurodegenerative diseases. This review will discuss an herbal constituent known as cinnamaldehyde (CA) with the neuroprotective potential to treat neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Accumulating evidence supports the notion that CA displays neuroprotective effects in AD and PD animal models by modulating neuroinflammation, suppressing oxidative stress, and improving the synaptic connection. CA exerts these effects through its action on multiple signaling pathways, including TLR4/NF-B, NLRP3, ERK1/2-MEK, NO, and Nrf2 pathways. To summarize, CA and its derivatives have been shown to improve pathological changes in AD and PD animal models, which may provide a new therapeutic option for neurodegenerative interventions. To this end, further experimental and clinical studies are required to prove the neuroprotective effects of CA and its derivatives.
神经退行性疾病是一种破坏性且无法治愈的疾病，其特征是神经元功能障碍。实验和临床研究的主要重点是针对天然产物及其活性成分对神经退行性疾病的影响。本综述将讨论一种名为肉桂醛（CA）的草药成分，它具有神经保护潜力，可以治疗神经退行性疾病，如阿尔茨海默病（AD）和帕金森病（PD）。越来越多的证据支持这样一种观点，即 CA 通过调节神经炎症、抑制氧化应激和改善突触连接，在 AD 和 PD 动物模型中显示出神经保护作用。CA 通过作用于多个信号通路发挥这些作用，包括 TLR4/NF-B、NLRP3、ERK1/2-MEK、NO 和 Nrf2 通路。总之，CA 及其衍生物已被证明可改善 AD 和 PD 动物模型中的病理变化，这可能为神经退行性疾病的干预提供新的治疗选择。为此，需要进一步的实验和临床研究来证明 CA 及其衍生物的神经保护作用。
