Department of Obstetrics and Gynecology, University of Toyama, Toyama 930-8555, Japan.
Department of Pediatrics, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
Int J Mol Sci. 2020 May 7;21(9):3298. doi: 10.3390/ijms21093298.
Placental homeostasis is directly linked to fetal well-being and normal fetal growth. Placentas are sensitive to various environmental stressors, including hypoxia, endoplasmic reticulum stress, and oxidative stress. Once placental homeostasis is disrupted, the placenta may rebel against the mother and fetus. Autophagy is an evolutionally conservative mechanism for the maintenance of cellular and organic homeostasis. Evidence suggests that autophagy plays a crucial role throughout pregnancy, including fertilization, placentation, and delivery in human and mouse models. This study reviews the available literature discussing the role of autophagy in preeclampsia.
胎盘稳态与胎儿健康和正常生长直接相关。胎盘对各种环境应激源敏感，包括缺氧、内质网应激和氧化应激。一旦胎盘稳态被破坏，胎盘可能会反抗母亲和胎儿。自噬是维持细胞和有机体内稳态的一种进化保守机制。有证据表明，自噬在人类和小鼠模型的受精、胎盘形成和分娩等整个妊娠过程中都起着至关重要的作用。本研究综述了目前讨论自噬在子痫前期中作用的文献。
