Nizze H, Kändler U
Institut für Pathologische Anatomie Wilhelm-Pieck-Universität Rostock.
Zentralbl Gynakol. 1988;110(20):1296-302.
282 female patients with histologically confirmed fibroadenomas (71), mastopathies (187) and breast carcinomas (24) were questioned for hormonal contraception. 144 women had taken oral steroid contraceptive pills, 138 denied such treatment. Statistically significant differences could not be observed in the occurrence of the breast diseases studied. Under hormonal contraception, fibroadenomas were found in 28% (without contraception in 22%), simple mastopathies in 41% (without in 40%), proliferative mastopathies in 22% (without in 30%) and mammary carcinomas in 9% (without in 8%) of the corresponding cases. The histological finding of a so-called apocrine metaplasia was found in all the diseases (except carcinomas) more frequent in the contraceptive group. Histometrically, the breast parenchyma showed a changing lobular hyperplasia under hormonal contraception in all the disease groups studied. An influence of questioned gynecological risk factors for a breast carcinoma was not striking in the women with and without hormonal contraception.
对282名经组织学确诊为纤维腺瘤（71例）、乳腺病（187例）和乳腺癌（24例）的女性患者进行了激素避孕方面的询问。144名女性服用过口服甾体避孕药，138名否认接受过此类治疗。在所研究的乳腺疾病的发生率方面未观察到统计学上的显著差异。在激素避孕组中，相应病例的纤维腺瘤发生率为28%（未避孕组为22%），单纯乳腺病为41%（未避孕组为40%），增生性乳腺病为22%（未避孕组为30%），乳腺癌为9%（未避孕组为8%）。在所有疾病（除癌症外）中，所谓的大汗腺化生的组织学发现，在避孕组中更为常见。从组织测量学来看，在所研究的所有疾病组中，激素避孕下乳腺实质均出现了变化的小叶增生。在有或没有激素避孕的女性中，所询问的乳腺癌妇科危险因素的影响并不显著。
