Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, I, Tehran, R, Iran.
Nutr J. 2020 May 11;19(1):40. doi: 10.1186/s12937-020-00560-w.
Although adherence to "Dietary Approaches to Stop Hypertension" (DASH) dietary pattern has been linked with reduced risk of several cancers. To our knowledge no studies have examined the association between the DASH dietary pattern and risk of gastric cancer. This study was performed to investigate the association between adherence to the DASH dietary pattern and odds of gastric cancer in Iran.
This hospital-based case-control study was conducted on 178 histo-pathologically confirmed patients with gastric cancer and 276 sex-matched healthy controls. A validated 146-item Diet History Questionnaire (DHQ) was used to assess participants' usual dietary intakes. The DASH dietary pattern scores were calculated using the method introduced by Fung. Unconditional logistic regression, in which potential confounders were taken into account, was applied to determine the association of adherence to the DASH dietary pattern and odds of gastric cancer.
Mean age of cases and controls were 60.8 and 53.2 y, respectively. After controlling for age, sex and energy intakes, participants in the highest tertile were 62% less likely to have gastric cancer than those in the lowest tertile (OR 0.38; 95% CI 0.22,0.65; P < 0.004). Further adjustment for other potential confounders, including education, marital status, residential place, alcohol intake and smoking, did not change the association dramatically (OR 0.44; 95% CI 0.25, 0.78; P = 0.005). Even after additional controlling for H-Pylori infection and BMI, greatest adherence to the DASH dietary pattern was associated with a 54% decreased risk of gastric cancer (OR 0.46; 95% CI 0.26, 0.83; P = 0.01).
Adherence to the DASH dietary pattern was associated with lower gastric cancer risk in this case-control study.
尽管遵循“停止高血压的饮食方法”（DASH）饮食模式与降低多种癌症的风险有关。据我们所知，尚无研究探讨 DASH 饮食模式与胃癌风险之间的关系。本研究旨在调查伊朗人群中遵循 DASH 饮食模式与胃癌风险之间的关系。
本病例对照研究以 178 例经组织病理学证实的胃癌患者和 276 名性别匹配的健康对照为研究对象。采用经过验证的 146 项饮食史问卷（DHQ）评估参与者的日常饮食摄入量。采用 Fung 介绍的方法计算 DASH 饮食模式评分。应用条件 logistic 回归，考虑到潜在混杂因素，确定了 DASH 饮食模式的依从性与胃癌风险之间的关联。
病例组和对照组的平均年龄分别为 60.8 岁和 53.2 岁。在控制年龄、性别和能量摄入后，最高三分位组的胃癌发病风险比最低三分位组低 62%（OR 0.38；95%CI 0.22，0.65；P<0.004）。进一步调整其他潜在混杂因素，包括教育程度、婚姻状况、居住地点、饮酒和吸烟，并未显著改变这种关联（OR 0.44；95%CI 0.25，0.78；P=0.005）。即使在进一步控制 H-Pylori 感染和 BMI 后，最大程度地遵循 DASH 饮食模式与胃癌风险降低 54%相关（OR 0.46；95%CI 0.26，0.83；P=0.01）。
在本病例对照研究中，DASH 饮食模式的依从性与较低的胃癌风险相关。
