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Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial.万古霉素或达托霉素联合与不联合抗葡萄球菌β-内酰胺类药物治疗耐甲氧西林金黄色葡萄球菌菌血症患者的死亡率、菌血症、复发或治疗失败的影响：一项随机临床试验。
JAMA. 2020 Feb 11;323(6):527-537. doi: 10.1001/jama.2020.0103.
2
Efficacy of Early Oral Switch with β-Lactams for Low-Risk Bacteremia.β-内酰胺类药物早期口服转换治疗低危菌血症的疗效。
Antimicrob Agents Chemother. 2020 Jun 23;64(7). doi: 10.1128/AAC.02345-19.
3
Pathogens causing central-line-associated bloodstream infections in acute-care hospitals-United States, 2011-2017.2011 - 2017年美国急症医院中导致中心静脉导管相关血流感染的病原体
Infect Control Hosp Epidemiol. 2020 Mar;41(3):313-319. doi: 10.1017/ice.2019.303. Epub 2020 Jan 9.
4
Efficacy of seven and fourteen days of antibiotic treatment in uncomplicated Staphylococcus aureus bacteremia (SAB7): study protocol for a randomized controlled trial.七天和十四天抗生素治疗方案对单纯金黄色葡萄球菌菌血症（SAB7）的疗效：一项随机对照试验的研究方案。
Trials. 2019 May 2;20(1):250. doi: 10.1186/s13063-019-3357-9.
5
Changing Characteristics of Staphylococcus aureus Bacteremia: Results From a 21-Year, Prospective, Longitudinal Study.金黄色葡萄球菌菌血症特征的变化：一项为期21年的前瞻性纵向研究结果
Clin Infect Dis. 2019 Nov 13;69(11):1868-1877. doi: 10.1093/cid/ciz112.
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Vital Signs: Epidemiology and Recent Trends in Methicillin-Resistant and in Methicillin-Susceptible Staphylococcus aureus Bloodstream Infections - United States.生命体征：耐甲氧西林和甲氧西林敏感金黄色葡萄球菌血流感染的流行病学和近期趋势 - 美国。
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Clin Infect Dis. 2019 Jul 18;69(3):381-387. doi: 10.1093/cid/ciy916.
9
Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia: A Randomized Clinical Trial.基于算法的治疗与常规护理对葡萄球菌菌血症患者临床疗效和严重不良事件的影响：一项随机临床试验。
JAMA. 2018 Sep 25;320(12):1249-1258. doi: 10.1001/jama.2018.13155.
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Considerations for Clinical Trials of Staphylococcus aureus Bloodstream Infection in Adults.成人金黄色葡萄球菌血流感染临床试验的考虑因素。
Clin Infect Dis. 2019 Feb 15;68(5):865-872. doi: 10.1093/cid/ciy774.

早期血培养阳性菌血症的抗生素转换：应者云集，择者寥寥。

Early Oral Antibiotic Switch for Bacteremia: Many Are Called, but Few Are Chosen.

机构信息

Duke University Medical Center, Durham, North Carolina, USA

Duke Clinical Research Institute, Durham, North Carolina, USA.

出版信息

Antimicrob Agents Chemother. 2020 Jun 23;64(7). doi: 10.1128/AAC.00317-20.

DOI:10.1128/AAC.00317-20
PMID:32393495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7317999/
Abstract

bacteremia (SAB) is a complicated, high-risk disease. For selected low-risk SAB, the role of oral antibiotic stepdown therapy is unknown. Bupha-Intr et al. report a retrospective cohort of low-risk SAB patients who did well with a short duration of intravenous antibiotics, followed by an additional ∼10 days of oral antibiotics, primarily using beta-lactams. Prospective trials will help further define the efficacy of this approach.

摘要

菌血症（SAB）是一种复杂的、高危疾病。对于某些特定的低危 SAB，口服抗生素降阶梯治疗的作用尚不清楚。Bupha-Intr 等人报告了一组低危 SAB 患者的回顾性队列研究，这些患者在接受短疗程静脉抗生素治疗后，接着再使用约 10 天的口服抗生素，主要使用β-内酰胺类药物，效果良好。前瞻性试验将有助于进一步确定这种方法的疗效。