早期血培养阳性菌血症的抗生素转换：应者云集，择者寥寥。
Early Oral Antibiotic Switch for Bacteremia: Many Are Called, but Few Are Chosen.
机构信息
Duke University Medical Center, Durham, North Carolina, USA
Duke Clinical Research Institute, Durham, North Carolina, USA.
出版信息
Antimicrob Agents Chemother. 2020 Jun 23;64(7). doi: 10.1128/AAC.00317-20.
Abstract
bacteremia (SAB) is a complicated, high-risk disease. For selected low-risk SAB, the role of oral antibiotic stepdown therapy is unknown. Bupha-Intr et al. report a retrospective cohort of low-risk SAB patients who did well with a short duration of intravenous antibiotics, followed by an additional ∼10 days of oral antibiotics, primarily using beta-lactams. Prospective trials will help further define the efficacy of this approach.
摘要
菌血症（SAB）是一种复杂的、高危疾病。对于某些特定的低危 SAB，口服抗生素降阶梯治疗的作用尚不清楚。Bupha-Intr 等人报告了一组低危 SAB 患者的回顾性队列研究，这些患者在接受短疗程静脉抗生素治疗后，接着再使用约 10 天的口服抗生素，主要使用β-内酰胺类药物，效果良好。前瞻性试验将有助于进一步确定这种方法的疗效。
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