Olsen E B, Trier K, Eldov K, Ammitzbøll T
Department of Dermatologi, Rigshospital, University of Copenhagen, Denmark.
Acta Obstet Gynecol Scand. 1988;67(6):539-42. doi: 10.3109/00016348809029866.
Abnormal concentrations of glycosaminoglycans (GAG) have been reported for various types of tumors, suggesting that they may play a role in neoplasia. The correlation between the content of individual GAGs was studied in breast tumor tissues. The total content of GAG was estimated by uronic acid analysis. The relative distributions of dermatan sulphate, heparan sulphate, hyaluronic acid and chondroitin sulphate were measured after cellulose acetate electrophoresis. Mammary tissue samples were obtained at the time of surgery from 11 women, 6 with fibroadenomata and 5 with carcinoma. From each patient, biopsies were obtained centrally in the tumor and perilesional areas adjacent to the tumor, and also from clinically uninvolved tissue in the same region. In the central areas, it was found that carcinoma had a significant increase in chondroitin sulphate and uronic acid content, and a significant decrease in dermatan sulphate content, as compared with fibroadenoma. The chondroitin sulphate content in perilesional carcinomatous tissue was significantly greater than in clinically uninvolved tissue.
已有报道称，多种类型肿瘤中糖胺聚糖（GAG）浓度异常，这表明它们可能在肿瘤形成过程中发挥作用。研究了乳腺肿瘤组织中各GAG含量之间的相关性。通过糖醛酸分析估算GAG的总含量。醋酸纤维素电泳后测量硫酸皮肤素、硫酸乙酰肝素、透明质酸和硫酸软骨素的相对分布。手术时从11名女性身上获取乳腺组织样本，其中6名患有纤维腺瘤，5名患有癌症。从每位患者身上，在肿瘤中央、肿瘤周边区域以及同一区域临床上未受累的组织中获取活检样本。在中央区域发现，与纤维腺瘤相比，癌组织中硫酸软骨素和糖醛酸含量显著增加，硫酸皮肤素含量显著降低。肿瘤周边癌组织中的硫酸软骨素含量明显高于临床上未受累的组织。
