Maideen Naina Mohamed Pakkir, Balasubramanian Rajkapoor
Pharmacologist, Dubai Health, Dubai, UAE.
Department of Pharmacology, J.K.K. Nattraja College of Pharmacy, Komarapalayam, India.
Infect Disord Drug Targets. 2025;25(4):e18715265304758. doi: 10.2174/0118715265304758240821113606.
A mystery pathogen that has not yet infected the entire world's population is predicted to be the cause of Disease X, which will be contagious. According to WHO scientists, 50 million people are expected to die from Disease X, which would be 20 times deadlier than coronavirus disease 2019 (COVID-19). Many international initiatives are currently in motion to get ready for future pandemics. These include updating the International Health Regulation and the European Legislation, establishing the Health Emergency Preparedness and Response Authority (HERA), establishing international hubs, taking on the international challenge of developing a vaccine for Disease X within 100 days of recognition of emerging Pathogen X, and updating the preparedness plan of National Institute of Allergy and Infectious Diseases. Our current review's main objective is to determine whether black seeds (Nigella Sativa) can manage Disease X. It has been established by several studies that black seeds () have antiviral, antibacterial, antimicrobial, immunomodulatory, anti-inflammatory, and antioxidant properties, which would be useful in the management of Disease X. Black seeds ) may be utilized in conjunction with supportive care and symptomatic therapy to manage Disease X in early phases. Future randomized controlled clinical trials would further evaluate the safety and effectiveness of black seeds (N. sativa) in patients with Disease X.
一种尚未感染全球所有人的神秘病原体预计将成为X疾病的病因,该疾病具有传染性。据世界卫生组织的科学家称,预计将有5000万人死于X疾病,其致死率将是2019冠状病毒病(COVID-19)的20倍。目前许多国际举措正在开展,为未来的大流行做好准备。这些举措包括更新《国际卫生条例》和欧洲立法、设立卫生应急准备与响应机构(HERA)、建立国际中心、应对在识别出新型病原体X后100天内研发出针对X疾病疫苗的国际挑战,以及更新美国国立过敏与传染病研究所的防范计划。我们当前综述的主要目的是确定黑种草籽是否能应对X疾病。多项研究已证实,黑种草籽具有抗病毒、抗菌、抗微生物、免疫调节、抗炎和抗氧化特性,这些特性在应对X疾病时可能会有所帮助。黑种草籽可与支持性护理和对症治疗联合使用,在早期阶段应对X疾病。未来的随机对照临床试验将进一步评估黑种草籽对X疾病患者的安全性和有效性。