唾液刺激对硫氰酸盐作为吸烟状况指标有效性的影响。

The influence of salivary stimulation on the validity of thiocyanate as an index of smoking status.

作者信息

O'Connell K A, Gerkovich M M, Fears B A, Cook M R

机构信息

Midwest Research Institute, Kansas City, MO 64110.

出版信息

Addict Behav. 1988;13(4):383-6. doi: 10.1016/0306-4603(88)90045-7.

DOI:10.1016/0306-4603(88)90045-7

PMID:3239470

Abstract

This study investigated the effects of salivary stimulation on thiocyanate (SCN) levels. A device for collecting parotid saliva that allowed for the measurement of flow rate was used in stimulated and nonstimulated conditions with six subjects. Results indicated that SCN levels exhibited considerable within-subject variability and were inversely related to flow rate. Under stimulated conditions, SCN levels stabilized in 3 min. Under nonstimulated conditions. SCN levels stabilized in 26 min. Although mean SCN levels were higher for smokers than nonsmokers, considerable overlap was observed such that misclassification of both smokers and nonsmokers could occur if cut-off points were not adjusted for flow rate conditions. Suggestions for standardizing stimulated conditions for collecting salivary SCN samples are discussed.

摘要

本研究调查了唾液刺激对硫氰酸盐（SCN）水平的影响。使用一种能够测量流速的腮腺唾液收集装置，在刺激和非刺激条件下对6名受试者进行了研究。结果表明，SCN水平在受试者内部表现出相当大的变异性，并且与流速呈负相关。在刺激条件下，SCN水平在3分钟内稳定下来。在非刺激条件下，SCN水平在26分钟内稳定下来。尽管吸烟者的平均SCN水平高于非吸烟者，但观察到有相当大的重叠，如果不根据流速条件调整临界点，可能会出现吸烟者和非吸烟者的错误分类。文中还讨论了标准化唾液SCN样本收集刺激条件的建议。