Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Biotechnol Appl Biochem. 2021 Apr;68(2):404-410. doi: 10.1002/bab.1938. Epub 2020 Jun 8.
Release and storage of energy can be regulated by the metabolic parameter dependent on the central nervous system. Macrophages are one of the most professional antigen-presenting cells that are formed by the accumulation of dead or damaged cells or in response to the infection, which has the main function of phagocytosis, secretion of cytokines, and presenting antigen to T cells. A proper immune response is needed for the production of effector cytokines along with comprehensive and rapid cell proliferation and growth. Activation of the immune system and immune cells is needed to increase glucose metabolism. When the immune system responds to pathogens, chemokines inform immune cells such as macrophages and T cells to travel to the infected area. Although glucose is vital for the proper function of immune cells and their proliferation, a high amount of glucose may lead to impaired function of the immune system and pathological conditions. However, a suitable amount of glucose is indispensable for the immune system, but its elevated amount leads to excessive proinflammatory cytokines production. In this study, we focused on the master regulatory role of glucose on the immune system.
能量的释放和储存可以通过依赖于中枢神经系统的代谢参数来调节。巨噬细胞是最专业的抗原呈递细胞之一，它是由死亡或受损细胞的积累或对感染的反应而形成的，主要功能是吞噬、分泌细胞因子和向 T 细胞呈递抗原。为了产生效应细胞因子，需要进行全面而快速的细胞增殖和生长。需要激活免疫系统和免疫细胞来增加葡萄糖代谢。当免疫系统对病原体做出反应时，趋化因子会通知巨噬细胞和 T 细胞等免疫细胞前往感染区域。虽然葡萄糖对于免疫细胞的正常功能及其增殖至关重要，但大量葡萄糖可能会导致免疫系统功能受损和病理状况。然而，适量的葡萄糖对于免疫系统是不可或缺的，但它的增加会导致过度的促炎细胞因子产生。在本研究中，我们专注于葡萄糖对免疫系统的主要调节作用。
