新型冠状病毒诊断的最新进展。
Recent progress on the diagnosis of 2019 Novel Coronavirus.
机构信息
The Chinese Peoples' Liberation Army 964 Hospital, Changchun, China.
College of Animal Sciences, Jilin University, Changchun, China.
出版信息
Transbound Emerg Dis. 2020 Jul;67(4):1485-1491. doi: 10.1111/tbed.13620. Epub 2020 May 31.
Abstract
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. Therefore, convenient, timely and accurate detection of SARS-CoV-2 is urgently needed. Here, we review the types, characteristics and shortcomings of various detection methods, as well as perspectives for the SARS-CoV-2 diagnosis. Clinically, nucleic acid-based methods are sensitive but prone to false-positive. The antibody-based method has slightly lower sensitivity but higher accuracy. Therefore, it is suggested to combine the two methods to improve the detection accuracy of COVID-19.
摘要
由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的 2019 年冠状病毒病（COVID-19）已成为全球性大流行。因此，迫切需要方便、及时和准确地检测 SARS-CoV-2。在这里，我们综述了各种检测方法的类型、特点和缺点，以及 SARS-CoV-2 诊断的展望。临床上，基于核酸的方法具有较高的灵敏度，但易出现假阳性。基于抗体的方法灵敏度略低，但准确性更高。因此，建议将两种方法结合使用，以提高 COVID-19 的检测准确性。
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