Gong Chen, Lan Xiaoyan
Respiratory Medicine Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China.
Experiment Center, Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China.
Medicine (Baltimore). 2025 Aug 15;104(33):e43918. doi: 10.1097/MD.0000000000043918.
This study explores the comfort level of lidocaine-soaked swab for nucleic acid detection of COVID-19 (Coronavirus Disease 2019) patients. Oropharyngeal and nasopharyngeal secretions from COVID-19 patients were collected using lidocaine-soaked swabs.
COVID-19 patients were randomly divided into experimental group and control group, with 25 patients in each group. The first oropharyngeal and nasopharyngeal swabs (experimental group) was be soaked in lidocaine hydrochloride injection. The control group was tested for novel coronavirus nucleic acid by routine nasopharyngeal/oropharyngeal swabs. Then, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA) was detected in 2 groups by real-time reverse transcription-polymerase chain reaction (RT-PCR). Participants' discomfort was assessed by a visual analog scale. Then, the discomfort and cycle threshold (Ct) values after sampling were compared between the 2 groups.
A total of 50 patients were enrolled in the study. There were no lidocaine-related complications during sampling. COVID-19 inpatients feel more comfortable with the use of lidocaine-soaked swabs (nasopharyngeal 3.44 ± 1.42 vs 5.68 ± 0.95, P < .01; oropharyngeal 4.4 ± 1.53 vs 8.92 ± 0.91, P < .01). Ct values of nasopharyngeal swab specimens were generally lower than those of oropharyngeal swab specimens. There was no statistically significant difference between Ct value results of the 2 groups. The use of lidocaine-soaked swabs for sampling of COVID-19 reduces patients' discomfort. This method is worth popularizing in novel coronavirus sampling.
The use of lidocaine-soaked swabs for sampling of COVID-19 reduces patients' discomfort, which it has no obvious effect on Ct value. This method is worth popularizing in novel coronavirus sampling.
本研究探讨利多卡因浸润拭子用于新型冠状病毒肺炎（COVID-19）患者核酸检测时的舒适度。使用利多卡因浸润拭子采集COVID-19患者的口咽和鼻咽分泌物。
将COVID-19患者随机分为实验组和对照组，每组25例。第一口咽和鼻咽拭子（实验组）浸泡于盐酸利多卡因注射液中。对照组采用常规鼻咽/口咽拭子检测新型冠状病毒核酸。然后，通过实时逆转录-聚合酶链反应（RT-PCR）检测两组中的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）核糖核酸（RNA）。采用视觉模拟评分法评估参与者的不适程度。然后，比较两组采样后的不适程度和循环阈值（Ct）值。
本研究共纳入50例患者。采样过程中未出现与利多卡因相关的并发症。使用利多卡因浸润拭子，COVID-19住院患者感觉更舒适（鼻咽部3.44±1.42 vs 5.68±0.95，P<.01；口咽部4.4±1.53 vs 8.92±0.91，P<.01）。鼻咽拭子标本的Ct值普遍低于口咽拭子标本。两组Ct值结果之间无统计学显著差异。使用利多卡因浸润拭子对COVID-19进行采样可减轻患者的不适。该方法值得在新型冠状病毒采样中推广。
使用利多卡因浸润拭子对COVID-19进行采样可减轻患者的不适，且对Ct值无明显影响。该方法值得在新型冠状病毒采样中推广。
