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腹腔镜阑尾切除术和胆囊切除术患者出院后的阿片类药物处方。

Post-discharge opioid prescribing after laparoscopic appendicectomy and cholecystectomy.

机构信息

Hunter Surgical Clinical Research Unit, John Hunter Hospital, Newcastle, New South Wales, Australia.

Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.

出版信息

ANZ J Surg. 2020 Jun;90(6):1014-1018. doi: 10.1111/ans.15882. Epub 2020 May 12.

DOI:10.1111/ans.15882
PMID:32395916
Abstract

BACKGROUND

Opioid over-prescription following surgery is a significant public health issue in most developed countries. Multiple studies have been conducted in the USA demonstrating and investigating the issue; however, there is a lack of literature addressing this topic in the Australian setting. The aim of this study is to review prescribing practices at an Australian tertiary referral hospital on discharge in patients having undergone laparoscopic cholecystectomy (LC) or laparoscopic appendicetomy (LA). Additionally, to identify potential factors which influence medical officer prescribing practices.

METHODS

A retrospective observational study on opioid prescribing practice on all patients who underwent LC or LA over a 12-month period at an Australian tertiary referral hospital.

RESULTS

A total of 435 patients (223 LC, 214 LA) were prescribed a mean opioid dose on discharge of 25 oral morphine milli-equivalents (range 0-180 morphine milli-equivalents). Less opioids were prescribed following elective procedures (42% versus 10%, P < 0.001). There is a downward trend of opioid prescribing on discharge as the Junior Medical Officer clinical year progresses (P < 0.001).

CONCLUSIONS

This study demonstrates a lower rate of opiate prescription on discharge for LC and LA in an Australian setting when compared to the US data. There is a wide diversity of prescribing demonstrated. This indicates the need for better training of opioid prescribers to reduce over-prescribing.

摘要

背景

在大多数发达国家,手术后阿片类药物过量处方是一个重大的公共卫生问题。美国已经进行了多项研究来证明和调查这个问题;然而,在澳大利亚的背景下,缺乏关于这个主题的文献。本研究旨在审查澳大利亚一家三级转诊医院在腹腔镜胆囊切除术(LC)或腹腔镜阑尾切除术(LA)患者出院时的处方实践,并确定影响医生处方实践的潜在因素。

方法

对澳大利亚一家三级转诊医院在 12 个月内接受 LC 或 LA 的所有患者的阿片类药物处方实践进行回顾性观察研究。

结果

共有 435 名患者(223 名 LC,214 名 LA)出院时平均开了 25 毫克口服吗啡等价物的阿片类药物(范围为 0-180 毫克吗啡等价物)。择期手术的阿片类药物处方量较少(42%对 10%,P<0.001)。随着初级医生临床年的进展,出院时阿片类药物的开具量呈下降趋势(P<0.001)。

结论

与美国数据相比,本研究表明在澳大利亚,LC 和 LA 出院时阿片类药物的处方率较低。处方的多样性很大。这表明需要更好地培训阿片类药物的开具者,以减少过度开具。

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