黏连蛋白生物学：从被动环到分子马达。
Cohesin Biology: From Passive Rings to Molecular Motors.
机构信息
Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 842 15 Bratislava, Slovakia.
Department of Genetics, Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovakia.
出版信息
Trends Genet. 2020 Jun;36(6):387-389. doi: 10.1016/j.tig.2020.03.001. Epub 2020 Mar 31.
The loop extrusion hypothesis postulated that extrusion of DNA loops through cohesin rings organizes genomes. Recent findings suggest that cohesin itself is a molecular motor that extrudes DNA. This has important implications not only for the organization of interphase chromatin but also for other processes where cohesin plays vital roles.
环挤出假说假定，通过黏合蛋白环挤出 DNA 环可组织基因组。最近的研究结果表明，黏合蛋白本身就是一种分子马达，可以挤出 DNA。这不仅对有丝分裂期染色质的组织有重要意义，而且对黏合蛋白发挥重要作用的其他过程也有重要意义。
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