McCubrey James A, Abrams Stephen L, Lertpiriyapong Kvin, Cocco Lucio, Ratti Stefano, Martelli Alberto M, Candido Saverio, Libra Massimo, Murata Ramiro M, Rosalen Pedro L, Lombardi Paolo, Montalto Giuseppe, Cervello Melchiorre, Gizak Agnieszka, Rakus Dariusz, Steelman Linda S
Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA.
Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA.
Adv Biol Regul. 2018 Jan;67:190-211. doi: 10.1016/j.jbior.2017.09.012. Epub 2017 Oct 3.
Over the past fifty years, society has become aware of the importance of a healthy diet in terms of human fitness and longevity. More recently, the concept of the beneficial effects of certain components of our diet and other compounds, that are consumed often by different cultures in various parts of the world, has become apparent. These "healthy" components of our diet are often referred to as nutraceuticals and they can prevent/suppress: aging, bacterial, fungal and viral infections, diabetes, inflammation, metabolic disorders and cardiovascular diseases and have other health-enhancing effects. Moreover, they are now often being investigated because of their anti-cancer properties/potentials. Understanding the effects of various natural products on cancer cells may enhance their usage as anti-proliferative agents which may be beneficial for many health problems. In this manuscript, we discuss and demonstrate how certain nutraceuticals may enhance other anti-cancer drugs to suppress proliferation of cancer cells.
在过去的五十年里，社会已经意识到健康饮食对于人类健康和长寿的重要性。最近，我们饮食中的某些成分以及世界各地不同文化中经常食用的其他化合物具有有益作用的概念已经变得明显。我们饮食中的这些“健康”成分通常被称为营养保健品，它们可以预防/抑制：衰老、细菌、真菌和病毒感染、糖尿病、炎症、代谢紊乱和心血管疾病，并具有其他增强健康的作用。此外，由于它们的抗癌特性/潜力，现在它们经常被研究。了解各种天然产物对癌细胞的影响可能会增加它们作为抗增殖剂的用途，这可能对许多健康问题有益。在本手稿中，我们讨论并展示了某些营养保健品如何增强其他抗癌药物以抑制癌细胞的增殖。
