College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE.
The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Viruses. 2020 May 10;12(5):526. doi: 10.3390/v12050526.
The COVID-19 pandemic is due to infection caused by the novel SARS-CoV-2 virus that impacts the lower respiratory tract. The spectrum of symptoms ranges from asymptomatic infections to mild respiratory symptoms to the lethal form of COVID-19 which is associated with severe pneumonia, acute respiratory distress, and fatality. To address this global crisis, up-to-date information on viral genomics and transcriptomics is crucial for understanding the origins and global dispersion of the virus, providing insights into viral pathogenicity, transmission, and epidemiology, and enabling strategies for therapeutic interventions, drug discovery, and vaccine development. Therefore, this review provides a comprehensive overview of COVID-19 epidemiology, genomic etiology, findings from recent transcriptomic map analysis, viral-human protein interactions, molecular diagnostics, and the current status of vaccine and novel therapeutic intervention development. Moreover, we provide an extensive list of resources that will help the scientific community access numerous types of databases related to SARS-CoV-2 OMICs and approaches to therapeutics related to COVID-19 treatment.
新型冠状病毒肺炎（COVID-19）是由新型严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染引起的累及下呼吸道的疾病。其症状谱从无症状感染到轻微呼吸道症状，再到与严重肺炎、急性呼吸窘迫和死亡相关的 COVID-19 致死形式。为应对这一全球危机，及时了解病毒基因组学和转录组学信息对于了解病毒的起源和全球传播、深入认识病毒的致病性、传播和流行病学，以及制定治疗干预、药物发现和疫苗开发策略至关重要。因此，本综述全面概述了 COVID-19 的流行病学、基因组病因、近期转录组图谱分析结果、病毒-人类蛋白相互作用、分子诊断以及疫苗和新型治疗干预措施的开发现状。此外，我们还提供了一个广泛的资源列表，帮助科学界访问与 SARS-CoV-2 组学和 COVID-19 治疗相关的治疗方法相关的多种类型数据库。
