1Schistosomiasis Consortium for Operational Research and Evaluation, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia.
2Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Am J Trop Med Hyg. 2020 Jul;103(1_Suppl):114-124. doi: 10.4269/ajtmh.19-0786.
For the past 10 years, the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE), funded by the Bill & Melinda Gates Foundation, has been supporting operational research to provide a stronger evidence base for controlling and moving toward elimination of schistosomiasis. The SCORE portfolio was developed and implemented with engagement from many stakeholders and sectors. Particular efforts were made to include endemic country neglected tropical disease program managers. Examples of the challenges we encountered include the need to balance rigor (e.g., conducting large cluster-randomized trials) with ensuring relevance to real-world settings, allowing for local contexts while standardizing key study aspects, adjusting to evolving technologies, and incorporating changing technologies into multiyear studies. The Schistosomiasis Consortium for Operational Research and Evaluation's findings and data and the collected specimens will continue to be useful in the years to come. Our experiences and lessons learned can benefit both program managers and researchers conducting similar work in the future.
在过去的 10 年里，由比尔及梅琳达·盖茨基金会资助的血吸虫病合作研究与评价组织（SCORE）一直在支持运营研究，为控制和迈向消除血吸虫病提供更有力的证据基础。SCORE 组合是在许多利益攸关方和部门的参与下制定和实施的。特别努力包括让受影响国家的被忽视热带病规划管理人员参与进来。我们遇到的挑战包括需要平衡严格性（例如，进行大规模的集群随机试验）和确保与现实环境的相关性，允许在标准化关键研究方面的同时考虑到当地情况，适应不断发展的技术，并将新技术纳入多年期研究。血吸虫病合作研究与评价组织的研究结果、数据和收集的标本在未来几年仍将具有重要意义。我们的经验和教训可以使未来从事类似工作的规划管理人员和研究人员受益。
