利用体外翻译将环状β-氨基酸掺入到肽中。
Ribosomal incorporation of cyclic β-amino acids into peptides using in vitro translation.
机构信息
Department of Chemical and Biological Engineering and Center for Synthetic Biology, Northwestern University, Evanston, IL 60208, USA.
Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, 78712 TX, USA.
出版信息
Chem Commun (Camb). 2020 May 27;56(42):5597-5600. doi: 10.1039/d0cc02121k.
PMID:32400780
Abstract
We demonstrate in vitro incorporation of cyclic β-amino acids into peptides by the ribosome through genetic code reprogramming. Further, we show that incorporation efficiency can be increased through the addition of elongation factor P.
摘要
我们通过遗传密码重编程证明了核糖体在体外将环β-氨基酸掺入肽中。此外，我们还表明，通过添加延伸因子 P 可以提高掺入效率。
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