David Carla, Elizalde-Hernández Alejandro, Barboza Andressa S, Cardoso Gabriela C, Santos Mateus B F, Moraes Rafael R
Biopathological Research Group, Faculty of Dentistry (GIBFO), University of the Andes Mérida, Mérida 5101, Venezuela.
Graduate Program in Dentistry, Universidade Federal de Pelotas, Pelotas 96015-560, Brazil.
Dent J (Basel). 2022 Oct 17;10(10):193. doi: 10.3390/dj10100193.
Cannabidiol (CBD) has been gaining increased attention in contemporary society but seems to have been little explored in dentistry. This scoping review mapped the scientific and technological scenarios related to the use of CBD in dentistry. Peer-reviewed publications were searched in five international databases, patents were searched in five technological platforms. In total, 11 articles and 13 patents involving CBD in dentistry-related applications were included. The countries contributing to most articles were Brazil (27.3%) and USA (18.2%). The studies involved experiments on animals (63.6%) and/or using bacteria or cells (36.4%), and no clinical study was found. Three different applications of CBD were observed: periodontal therapy (45.4%), aid for bone regeneration (27.3%), and general use in oral therapies (27.3%). Patent inventors were based in China (53.8%) or USA (46.2%). The patent claims were mainly compositions for oral care, tooth whitening, injury repair, antifungal, anti-inflammatory, and analgesic effects. A total of 76.9% of the patents were filed in association with a company. In general, research suggests that CBD has promising biological properties for applications in dentistry, whereas patents indicate that the current interest of industry relies on compositions for oral care. There appears to be extensive room available for research and technological applications of CBD in dentistry.
大麻二酚（CBD）在当代社会越来越受到关注，但在牙科领域似乎鲜有探索。本综述梳理了与CBD在牙科应用相关的科技情况。在五个国际数据库中检索了同行评审的出版物，在五个技术平台上检索了专利。总共纳入了11篇涉及CBD在牙科相关应用的文章和13项专利。贡献文章最多的国家是巴西（27.3%）和美国（18.2%）。这些研究涉及动物实验（63.6%）和/或使用细菌或细胞（36.4%），未发现临床研究。观察到CBD的三种不同应用：牙周治疗（45.4%）、促进骨再生（27.3%）和口腔治疗中的一般应用（27.3%）。专利发明者来自中国（53.8%）或美国（46.2%）。专利权利要求主要是用于口腔护理、牙齿美白、损伤修复、抗真菌、抗炎和镇痛作用的组合物。总共76.9%的专利是与公司联合申请的。总体而言，研究表明CBD在牙科应用中具有有前景的生物学特性，而专利表明目前行业的兴趣在于口腔护理组合物。CBD在牙科的研究和技术应用似乎有很大的空间。
