脑内细胞外囊泡的生理与病理机制研究进展
Physiological and pathological insights into exosomes in the brain.
机构信息
Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230001, China.
Neurodegenerative Disease Research Center, University of Science and Technology of China, Hefei, Anhui 230026, China.
出版信息
Zool Res. 2020 Jul 18;41(4):365-372. doi: 10.24272/j.issn.2095-8137.2020.043.
Exosomes are small vesicles secreted by all cell types in the brain and play a role in cell-cell communication through the transfer of cargo or encapsulation. Exosomes in the brain have considerable impact on neuronal development, activation, and regeneration. In addition, exosomes are reported to be involved in the onset and propagation of various neurodegenerative diseases. In this review, we discuss the content of exosomes derived from major cell types in the brain, and their function under physiological and pathological conditions.
外泌体是所有脑细胞分泌的小囊泡，通过传递货物或包裹在细胞间通讯中发挥作用。大脑中的外泌体对神经元的发育、激活和再生有很大的影响。此外，外泌体还被报道参与了各种神经退行性疾病的发生和发展。在这篇综述中，我们讨论了来源于大脑主要细胞类型的外泌体的内容，以及它们在生理和病理条件下的功能。
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