Liao Yuhui, Li Bin, Zhao Zheng, Fu Yu, Tan Qingqin, Li Xingyu, Wang Wei, Yin Jialing, Shan Hong, Tang Ben Zhong, Huang Xi
Center for Infection and Immunity, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, Guangdong, P.R. China.
Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, Guangdong, P.R. China.
ACS Nano. 2020 Jul 28;14(7):8046-8058. doi: 10.1021/acsnano.0c00586. Epub 2020 Jun 15.
Tuberculosis (TB) causes a global burden with its high rates of infection and death, especially the irrepressible threats of latent infection and drug resistance. Therefore, it is important to construct efficient theranostics for the prevention and control of TB. Herein, we created a targeted theranostic strategy for TB with a rifampicin-loaded aggregation-induced emission (AIE) carrier and performed testing in laboratory animals. The AIE carrier was constructed to localize in the granulomas and emit fluorescent signals at the early stage of infection, enabling the early diagnosis of TB. Subsequently, reactive oxygen species (ROS) were generated to eradicate infection, and the loaded rifampicin (RIF) was released for the synergistic treatment of persistent bacteria. Furthermore, targeted TB therapy was performed with the light-controlled release of ROS and accurate delivery of RIF, which realizes an anti-infection effect, providing an especially important treatment for drug-resistant TB. Thus, targeted theranostics for TB in laboratory animals possess the potential to become granulomas-tracking and anti-infection strategies for the diagnosis and treatment of TB.
结核病（TB）因其高感染率和死亡率，尤其是潜伏感染和耐药性带来的无法抑制的威胁，造成了全球负担。因此，构建高效的诊疗方法对于结核病的预防和控制至关重要。在此，我们利用负载利福平的聚集诱导发光（AIE）载体创建了一种针对结核病的靶向诊疗策略，并在实验动物中进行了测试。AIE载体被构建为定位于肉芽肿并在感染早期发出荧光信号，从而实现结核病的早期诊断。随后，产生活性氧（ROS）以根除感染，并且释放负载的利福平（RIF）用于协同治疗持续存在的细菌。此外，通过光控释放ROS和精确递送RIF进行靶向结核病治疗，实现了抗感染效果，为耐药结核病提供了特别重要的治疗方法。因此，实验动物中针对结核病的靶向诊疗方法具有成为结核病诊断和治疗的肉芽肿追踪及抗感染策略的潜力。
