Gatica Damián, Klionsky Daniel J
Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan , Ann Arbor, MI, USA.
Autophagy. 2020 Jun;16(6):973-974. doi: 10.1080/15548627.2020.1756665.
AMPK is one of the main regulators of energy homeostasis in the cell, achieving this role in part by upregulating autophagy in times of nutrient deprivation. Previous reports have described several AMPK substrates involved in autophagy regulation; however, there are still undiscovered AMPK downstream effectors that could play an important role in autophagy. In a new article, Dohmen et al. discovered that the CCNY-CDK16 complex is a novel AMPK substrate involved in autophagy activation.
AMPK是细胞能量稳态的主要调节因子之一，部分通过在营养缺乏时上调自噬来发挥这一作用。先前的报道描述了几种参与自噬调节的AMPK底物；然而，仍有未被发现的AMPK下游效应物可能在自噬中发挥重要作用。在一篇新文章中，多门等人发现CCNY-CDK16复合物是一种参与自噬激活的新型AMPK底物。
