Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta GA 30303, USA.
Department of Anesthesiology, West China Hospital, Chengdu 610000, China.
Chin J Nat Med. 2020 Apr;18(4):284-295. doi: 10.1016/S1875-5364(20)30036-4.
Carbon monoxide (CO) as one of the three important endogenously produced signaling molecules, termed as "gasotransmitter," has emerged as a promising therapeutic agent for treating various inflammation and cellular-stress related diseases. In this review, we discussed CO's evolution from a well-recognized toxic gas to a signaling molecule, and the effort to develop different approaches to deliver it for therapeutic application. We also summarize recently reported chemistry towards different CO delivery forms.
一氧化碳（CO）作为三种重要的内源性信号分子之一，被称为“气体递质”，已成为治疗各种炎症和细胞应激相关疾病的有前途的治疗剂。在这篇综述中，我们讨论了 CO 从一种公认的有毒气体到信号分子的演变，以及为了治疗应用而开发不同方法来输送它的努力。我们还总结了最近报道的针对不同 CO 输送形式的化学方法。
