Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Medical University Eye Hospital, Tianjin, China.
Horm Metab Res. 2020 May;52(5):264-279. doi: 10.1055/a-1143-6024. Epub 2020 May 13.
The associations between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of type 2 diabetic retinopathy (DR) - proliferative diabetic retinopathy (PDR), and nonproliferative diabetic retinopathy (NPDR) - remain unclear. A systematic search and meta-analysis using odds ratio (OR) with 95% confidence interval (CI) was performed to evaluate the association. Our study concluded 26 studies containing 10 single nucleotide polymorphisms (SNPs). In Asian populations, rs3025039 polymorphism was associated with DR risk, while in overall populations and Caucasians, the DR risk was increased by association with rs2010963. There was a significant association between rs25648 and rs833061 and DR risk in Caucasians. DR risks were found to be significantly associated between rs3025021, rs13207351, and rs2146323 in either overall populations, Caucasians or Asians. Besides, in overall and Asian populations, rs699947 and rs3025039 were associated with PDR risk. rs1570360, rs3025039, and rs833061 played a key role in PDR etiology in Caucasians. rs2010963 was associated with increased risk of PDR in overall populations. A significant association between rs699947, rs3025039, and rs833061 and NPDR risk in overall populations and Asians was found. A significant association was observed between rs2010963 and increased NPDR risk in overall and Caucasian populations. This study provides a new insight into the parthenogenesis of diabetic retinopathy. Targeting VEGF SNPs may be a potential of therapeutic approach for the treatment of DR, PDR, and NPDR.
血管内皮生长因子 (VEGF) 基因多态性与 2 型糖尿病视网膜病变 (DR)-增生性糖尿病视网膜病变 (PDR) 和非增生性糖尿病视网膜病变 (NPDR) 风险之间的关联尚不清楚。使用优势比 (OR) 及其 95%置信区间 (CI) 进行了系统搜索和荟萃分析，以评估相关性。我们的研究共包括 26 项研究，其中包含 10 个单核苷酸多态性 (SNP)。在亚洲人群中，rs3025039 多态性与 DR 风险相关，而在总体人群和白种人群中，与 rs2010963 相关的 DR 风险增加。rs25648 和 rs833061 与白种人群中的 DR 风险之间存在显著关联。在总体人群、白种人群或亚洲人群中，rs3025021、rs13207351 和 rs2146323 与 DR 风险显著相关。此外，在总体人群和亚洲人群中，rs699947 和 rs3025039 与 PDR 风险相关。rs1570360、rs3025039 和 rs833061 在白种人群中对 PDR 的病因学起关键作用。rs2010963 与总体人群 PDR 风险增加相关。rs699947、rs3025039 和 rs833061 与总体人群和亚洲人群 NPDR 风险之间存在显著关联。rs2010963 与总体人群和白种人群 NPDR 风险增加之间存在显著关联。本研究为糖尿病视网膜病变的发病机制提供了新的见解。针对 VEGF SNPs 可能是治疗 DR、PDR 和 NPDR 的潜在治疗方法。
