Department of General Surgery, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, 200240, China.
Department of Endoscopic Center, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, 200240, China.
BMC Gastroenterol. 2020 May 13;20(1):150. doi: 10.1186/s12876-020-01220-3.
Polyethylene glycol solution (PEG) is widely used for bowel preparation prior to colonoscopies. However, patients often exhibited adverse events as nausea, vomit and distention due to its uncomfortable tastes and potential side affects. This study aimed to evaluate the effectiveness and safety of concomitant use of green tea (GT) with PEG in bowel preparation prior to colonoscopy.
This was a prospective, randomized controlled study. It was conducted at an outpatient setting of colorectal surgery in a tertiary hospital. Patients aged 18 through 80 who were scheduled to undergo colonoscopy between August 2015 and February 2016 were randomly assigned into two groups, admitting either 2 L-PEG solutions with 1 L GT liquids or 2 L-PEG solutions only for bowel preparation. Admitted doses of PEG solutions, taste evaluation, adverse reactions (nausea and vomiting, distention and abdominal pain) were investigated by questionnaires. The bowel cleanliness of each patient was evaluated according to the Aronchick indicators.
A total of 116 patients were enrolled in this study (PEG+GT 59, PEG 57). Full compliances were achieved in 93.2% patients of group PEG+GT and 59.6% of group PEG (p < 0.001). Mean Aronchick scale between two groups were 2.0 ± 0.9 versus 2.2 ± 0.7 respectively (PEG+GT vs PEG, p = 0.296). Rates of adverse events as nausea and vomiting, abdominal pain in bowel preparation were significantly different between two groups (55.9% vs 77.2%, p = 0.015 and 13.6% vs 33.3%, p = 0.012). Patients in group PEG+GT who have probabilities to receive repeating colonoscopy had a higher willingness to accept PEG+GT again for bowel preparation, compared with PEG group (94.9% vs 57.9%, p < 0.001).
Concomitant use of green tea and polyethylene glycol may effectively reduce incidence of adverse events, increase compliances, with comparable bowel cleanliness in bowel preparation.
This trial was retrospectively registered on Feb 1st, 2019 (ChiCTR1900021178).
聚乙二醇溶液（PEG）广泛用于结肠镜检查前的肠道准备。然而，由于其口感不佳和潜在的副作用，患者常出现恶心、呕吐和腹胀等不良反应。本研究旨在评估绿茶（GT）与 PEG 联合用于结肠镜检查前肠道准备的有效性和安全性。
这是一项前瞻性、随机对照研究。在一家三级医院的肛肠外科门诊进行。2015 年 8 月至 2016 年 2 月期间，年龄在 18 至 80 岁之间、计划接受结肠镜检查的患者被随机分为两组，一组服用 2L-PEG 溶液加 1L GT 液，另一组仅服用 2L-PEG 溶液进行肠道准备。通过问卷调查患者的 PEG 溶液服用剂量、口感评价、不良反应（恶心和呕吐、腹胀和腹痛）。根据 Aronchick 指标评估每位患者的肠道清洁度。
本研究共纳入 116 例患者（PEG+GT 组 59 例，PEG 组 57 例）。PEG+GT 组 93.2%的患者完全依从，PEG 组 59.6%的患者完全依从（p<0.001）。两组的平均 Aronchick 评分分别为 2.0±0.9 与 2.2±0.7（PEG+GT 组与 PEG 组比较，p=0.296）。两组肠道准备期间恶心和呕吐、腹痛等不良反应发生率差异有统计学意义（55.9%比 77.2%，p=0.015 和 13.6%比 33.3%，p=0.012）。PEG+GT 组中需要重复结肠镜检查的患者再次接受 PEG+GT 肠道准备的意愿明显高于 PEG 组（94.9%比 57.9%，p<0.001）。
绿茶与聚乙二醇联合应用可有效降低不良反应发生率，提高依从性，肠道清洁度相当。
本试验于 2019 年 2 月 1 日（ChiCTR1900021178）进行了回顾性注册。
