Choi Hong Seok, Shim Chan Sup, Kim Gyu Won, Kim Jung Seok, Lee Sun-Young, Sung In-Kyung, Park Hyung Seok, Kim Jeong Hwan
1Digestive Disease Center, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea 2Department of Internal Medicine, Sahm Yook Hospital, Seoul, Korea.
Dis Colon Rectum. 2014 Oct;57(10):1220-7. doi: 10.1097/DCR.0000000000000195.
Many patients report discomfort because of the unpleasant taste of bowel preparation solutions.
This study aimed to determine whether adding orange juice to 2 L of polyethylene glycol plus ascorbic acid is effective for reducing patient discomfort and improving palatability during bowel preparation.
This was a single-blinded, randomized controlled trial.
The study was conducted at a tertiary referral hospital and a generalized hospital.
Consecutive outpatients and inpatients were randomly allocated to drink 2 L of polyethylene glycol-ascorbic acid or 2 L of polyethylene glycol-ascorbic acid with orange juice in a single dose or a split dose.
Tolerability, palatability score, willingness, and related adverse events were investigated by questionnaires. Bowel cleansing was rated using the Aronchick scale. Each score was graded on a 5-point scale.
A total of 107 patients, 53 in the orange juice group and 54 in the polyethylene glycol-ascorbic acid group who underwent elective colonoscopy were enrolled. The palatability score (mean ± SD) was higher in the orange juice group than in the control group (2.36 ± 0.76 vs 1.78 ± 0.88; p = 0.005). Nausea was less frequent in the orange juice group (26.4% vs 59.3%; p = 0.001). Total amount of bowel preparation ingested was not significantly different between the groups (p = 0.44). The bowel preparation score (mean ± SD) was not significantly different (1.49 ± 0.80 vs 1.43 ± 0.77; p = 0.94). Willingness to repeat the same process was higher in the orange juice group (90.4% vs 66.7%; p = 0.003).
This study is limited because only ambulatory patients were enrolled.
Orange juice intake before drinking 2 L of polyethylene glycol-ascorbic acid for colonoscopy can reduce patient discomfort, resulting in improved acceptability and patient compliance. This method is as effective for bowel cleansing as polyethylene glycol.
许多患者因肠道准备溶液味道不佳而感到不适。
本研究旨在确定在2升聚乙二醇加抗坏血酸中添加橙汁是否能有效减轻患者在肠道准备过程中的不适并改善口感。
这是一项单盲随机对照试验。
该研究在一家三级转诊医院和一家综合医院进行。
连续的门诊患者和住院患者被随机分配，单次或分剂量饮用2升聚乙二醇 - 抗坏血酸溶液或2升聚乙二醇 - 抗坏血酸加橙汁溶液。
通过问卷调查来调查耐受性、口感评分、意愿度及相关不良事件。使用阿隆奇克量表对肠道清洁情况进行评分。每项评分采用5分制。
共有107例接受择期结肠镜检查的患者入组，橙汁组53例，聚乙二醇 - 抗坏血酸组54例。橙汁组的口感评分（均值±标准差）高于对照组（2.36±0.76 vs 1.78±0.88；p = 0.005）。橙汁组恶心的发生率较低（26.4% vs 59.3%；p = 0.001）。两组摄入的肠道准备溶液总量无显著差异（p = 0.44）。肠道准备评分（均值±标准差）无显著差异（1.49±0.80 vs 1.43±0.77；p = 0.94）。橙汁组重复相同过程的意愿度更高（90.4% vs 66.7%；p = 0.003）。
本研究存在局限性，因为仅纳入了门诊患者。
在饮用2升用于结肠镜检查的聚乙二醇 - 抗坏血酸之前摄入橙汁可减轻患者不适，从而提高可接受性和患者依从性。该方法在肠道清洁方面与聚乙二醇同样有效。
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