全球努力定义 SARS-CoV-2 感染保护性免疫的人类遗传学。
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection.
机构信息
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller Unversity, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France; University of Paris, Imagine Institute, Paris, France; Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.
Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
出版信息
Cell. 2020 Jun 11;181(6):1194-1199. doi: 10.1016/j.cell.2020.05.016. Epub 2020 May 13.
SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers-individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease-present a unique opportunity to reveal human genetic determinants of infection and disease.
SARS-CoV-2 感染表现出巨大的个体间临床变异性，从无症状感染到致命疾病不等。人类遗传学在决定对病毒的临床反应中的作用尚不清楚。对异常值个体（尽管接触了病毒但仍未感染的个体和患有危及生命疾病的健康年轻患者）的研究提供了一个独特的机会，可以揭示感染和疾病的人类遗传决定因素。
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