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May statins and PCSK9 inhibitors be protective from COVID-19 in familial hypercholesterolemia subjects?

作者信息

Scicali Roberto, Di Pino Antonino, Piro Salvatore, Rabuazzo Agata M, Purrello Francesco

机构信息

Department of Clinical and Experimental Medicine, University of Catania, Italy.

Department of Clinical and Experimental Medicine, University of Catania, Italy.

出版信息

Nutr Metab Cardiovasc Dis. 2020 Jun 25;30(7):1068-1069. doi: 10.1016/j.numecd.2020.05.003. Epub 2020 May 13.

DOI:10.1016/j.numecd.2020.05.003
PMID:32405159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7217767/
Abstract
摘要

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本文引用的文献

1
Familial hypercholesterolaemia and COVID-19: triggering of increased sustained cardiovascular risk.家族性高胆固醇血症与2019冠状病毒病：引发持续升高的心血管风险
J Intern Med. 2020 Jun;287(6):746-747. doi: 10.1111/joim.13070. Epub 2020 Apr 22.
2
Arterial stiffness improvement after adding on PCSK9 inhibitors or ezetimibe to high-intensity statins in patients with familial hypercholesterolemia: A Two-Lipid Center Real-World Experience.家族性高胆固醇血症患者在高强度他汀类药物基础上加用 PCSK9 抑制剂或依折麦布对动脉僵硬度的改善作用：双脂质中心真实世界经验。
J Clin Lipidol. 2020 Mar-Apr;14(2):231-240. doi: 10.1016/j.jacl.2020.01.015. Epub 2020 Feb 4.
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.《武汉 2019 年新型冠状病毒感染的肺炎 138 例住院患者临床特征分析》
JAMA. 2020 Mar 17;323(11):1061-1069. doi: 10.1001/jama.2020.1585.
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Rewiring cellular networks by members of the Flaviviridae family.黄病毒科成员对细胞网络的重排。
Nat Rev Microbiol. 2018 Feb 12;16(3):125-142. doi: 10.1038/nrmicro.2017.170.
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Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection.恢复期 SARS 患者感染 12 年后的脂质代谢改变。
Sci Rep. 2017 Aug 22;7(1):9110. doi: 10.1038/s41598-017-09536-z.
6
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Atherosclerosis. 2017 Feb;257:164-171. doi: 10.1016/j.atherosclerosis.2016.12.019. Epub 2016 Dec 16.
7
Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1).前蛋白转化酶枯草溶菌素 9（PCSK9）可以介导低密度脂蛋白受体相关蛋白 1（LRP-1）的降解。
PLoS One. 2013 May 13;8(5):e64145. doi: 10.1371/journal.pone.0064145. Print 2013.
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Virology. 2013 Aug 1;442(2):132-47. doi: 10.1016/j.virol.2013.04.003. Epub 2013 May 2.
9
Increased expression of LDL receptor-related protein 1 during human cytomegalovirus infection reduces virion cholesterol and infectivity.在人类巨细胞病毒感染过程中 LDL 受体相关蛋白 1 的表达增加会降低病毒体胆固醇和感染力。
Cell Host Microbe. 2012 Jul 19;12(1):86-96. doi: 10.1016/j.chom.2012.05.012.
10
Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2.富含胆固醇的膜微区在严重急性呼吸综合征冠状病毒S蛋白与细胞受体血管紧张素转换酶2相互作用中的重要性。
Virology. 2008 Nov 25;381(2):215-21. doi: 10.1016/j.virol.2008.08.026. Epub 2008 Sep 23.