用于结直肠癌治疗的输入蛋白-11同源模型与植物化合物的对接分析。
Docking analysis of importin-11 homology model with the phyto compounds towards colorectal cancer treatment.
作者信息
Selvaraj Jayaraman, Ponnulakshmi Rajagopal, Abilasha Srinivasan, Nalini Devarajan, Vijayalakshmi Periyasamy, Vishnupriya Veeraraghavan, Mohan Surapaneni Krishna
机构信息
Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India.
Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India.
出版信息
Bioinformation. 2020 Feb 29;16(2):153-159. doi: 10.6026/97320630016153. eCollection 2020.
Colorectal cancer (CRC) is the most familiar malignancy worldwide. Hence, searching for novel therapeutic options is of highest priority. Therefore, it is of interest to design inhibitors to the protein target importin-11, which transports β-catenin linked to colon cancer cells. However, the structure of importin-11 is not known. Hence, we use a homology model of importin-11 to dock potential interactions with five phyto compounds using molecular interaction features for further consideration.
结直肠癌（CRC）是全球最常见的恶性肿瘤。因此，寻找新的治疗方案是当务之急。因此，设计针对蛋白质靶点输入蛋白-11的抑制剂具有重要意义，该蛋白可转运与结肠癌细胞相关的β-连环蛋白。然而，输入蛋白-11的结构尚不清楚。因此，我们利用输入蛋白-11的同源模型，通过分子相互作用特征对接与五种植物化合物的潜在相互作用，以供进一步研究。
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