用于结肠癌治疗的生物碱化合物与β-连环蛋白的分子对接分析
Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer.
作者信息
Ponnulakshmi Rajagopal, Vishnupriya Veeraraghavan, Mohan Surapaneni Krishna, Abilasha Srinivasan, Ramajayam Govindan, Vijayalakshmi Periyasamy, Rajalakshmi Manikkam, Selvaraj Jayaraman
机构信息
Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India.
Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India.
出版信息
Bioinformation. 2020 Mar 31;16(3):283-287. doi: 10.6026/97320630016283. eCollection 2020.
It is known that beta-catenin is associated with fibromatosis, sarcoma and mesenchymal tumor. Therefore, it is of interest to design an effective inhibtitor to the target protein beta-catenin. In this study, we report the molecular docking analysis of alkaloid compounds (aristolochicacid, cryptopleurine, demecolcine, fagaronine and thalicarpine) with beta-catenin for further consideration towards the design and development of potential inhintors for the treatmnet of colon cancer.
已知β-连环蛋白与纤维瘤病、肉瘤和间充质肿瘤有关。因此，设计一种针对靶蛋白β-连环蛋白的有效抑制剂是很有意义的。在本研究中，我们报告了生物碱化合物（马兜铃酸、隐品碱、秋水仙碱、法卡林二醇和唐松草品碱）与β-连环蛋白的分子对接分析，以便进一步考虑设计和开发用于治疗结肠癌的潜在抑制剂。
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