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Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19.单细胞转录组学揭示了一种独特的记忆样 NK 细胞亚群，该亚群随着年龄的增长而积累，并与 COVID-19 中的疾病严重程度相关。
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Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.早期 IFN-α 特征和持续功能障碍是严重 COVID-19 中 NK 细胞的显著特征。
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本文引用的文献

1
Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia.新型冠状病毒肺炎外周血淋巴细胞亚群特征变化。
J Infect Dis. 2020 May 11;221(11):1762-1769. doi: 10.1093/infdis/jiaa150.
2
Clinical and immunological features of severe and moderate coronavirus disease 2019.新型冠状病毒病 2019 重症和中度患者的临床和免疫学特征。
J Clin Invest. 2020 May 1;130(5):2620-2629. doi: 10.1172/JCI137244.
3
Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors.嵌合抗原受体修饰的自然杀伤细胞在 CD19 阳性淋巴肿瘤中的应用。
N Engl J Med. 2020 Feb 6;382(6):545-553. doi: 10.1056/NEJMoa1910607.
4
Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation.记忆性 CD4 T 细胞衍生的白介素-2 与病毒感染协同作用，加剧肺部炎症。
PLoS Pathog. 2019 Aug 14;15(8):e1007989. doi: 10.1371/journal.ppat.1007989. eCollection 2019 Aug.
5
Natural Killer Cells in the Lungs.肺部自然杀伤细胞。
Front Immunol. 2019 Jun 25;10:1416. doi: 10.3389/fimmu.2019.01416. eCollection 2019.
6
Dynamics of Sendai Virus Spread, Clearance, and Immunotherapeutic Efficacy after Hematopoietic Cell Transplant Imaged Noninvasively in Mice.造血细胞移植后仙台病毒在小鼠体内传播、清除及免疫治疗效果的动态变化：无创成像研究
J Virol. 2018 Jan 2;92(2). doi: 10.1128/JVI.01705-17. Print 2018 Jan 15.
7
Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69CD56 cells.人类肺自然杀伤细胞主要由高度分化的低功能 CD69CD56 细胞组成。
J Allergy Clin Immunol. 2017 Apr;139(4):1321-1330.e4. doi: 10.1016/j.jaci.2016.07.043. Epub 2016 Sep 23.
8
Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia.细胞因子诱导的记忆样自然杀伤细胞对髓系白血病表现出增强的反应。
Sci Transl Med. 2016 Sep 21;8(357):357ra123. doi: 10.1126/scitranslmed.aaf2341.
9
Inhibition of natural killer cell cytotoxicity by interleukin-6: implications for the pathogenesis of macrophage activation syndrome.白细胞介素-6 抑制自然杀伤细胞细胞毒性：对巨噬细胞活化综合征发病机制的影响。
Arthritis Rheumatol. 2015 Nov;67(11):3037-46. doi: 10.1002/art.39295.
10
Characterization and ex vivo Expansion of Human Placenta-Derived Natural Killer Cells for Cancer Immunotherapy.人胎盘来源自然杀伤细胞的鉴定和体外扩增及其在癌症免疫治疗中的应用。
Front Immunol. 2013 May 1;4:101. doi: 10.3389/fimmu.2013.00101. eCollection 2013.

The Promise and Peril of Natural Killer Cell Therapies in Pulmonary Infection.

作者信息

Rajaram Sanjeeth, Canaday Laura M, Ochayon David E, Rangel Kelly M, Ali Ayad, Gyurova Ivayla E, Krishnamurthy Durga, Fletcher Jonathan S, Reighard Seth D, Cox Andrew, Weirauch Matthew T, Kottyan Leah C, Deshmukh Hitesh, Zacharias William J, Borchers Michael T, Waggoner Stephen N

机构信息

Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Medical Sciences Undergraduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Immunology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

出版信息

Immunity. 2020 Jun 16;52(6):887-889. doi: 10.1016/j.immuni.2020.04.018. Epub 2020 May 13.

DOI:10.1016/j.immuni.2020.04.018
PMID:32405233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7219410/
Abstract
摘要