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白藜芦醇对肝细胞癌可能的保护作用。

Possible protective effects of resveratrol in hepatocellular carcinoma.

作者信息

Karabekir Seda Cetinkaya, Özgörgülü Aydan

机构信息

University of KTO Karatay, Faculty of Medicine, Department of Histology and Embryology, Konya, Turkey.

University of Necmettin Erbakan, Faculty of Meram Medicine, Department of Histology and Embryology, Konya, Turkey.

出版信息

Iran J Basic Med Sci. 2020 Jan;23(1):71-78. doi: 10.22038/IJBMS.2019.36821.8774.

DOI:10.22038/IJBMS.2019.36821.8774
PMID:32405350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7206832/
Abstract

OBJECTIVES

Resveratrol (RSV) is a naturally occurring plant polyphenol with cardioprotective, neuroprotective, immunoregulatory, and anticancer properties and is biologically effective against various diseases. This study aimed to investigate the chemopreventive effect of different doses of RSV against hepatocellular carcinoma (HCC) induced by diethylnitrosamine (DEN) in rats.

MATERIALS AND METHODS

The rats were randomly divided into six groups of seven rats each (n=42). The control group (group 1) was injected with saline, group 2 with dimethyl sulfoxide (DMSO), group 3 with DEN, group 4 with DEN and 50 mg/kg of RSV (DEN+RSV 50), group 5 with DEN and 75 mg/kg of RSV (DEN+RSV 75), and group 6 with DEN and 100 mg/kg of RSV (DEN+RSV 100). Pro-apoptotic Bax/anti-apoptotic Bcl-2 and tumor suppressor p53 markers were analyzed by immunostaining.

RESULTS

Superoxide dismutase, glutathione, and malondialdehyde concentrations were not statistically significant in DEN+RSV 100 group but were closest to the concentrations in control group. Liver function tests showed that enzyme activity (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyl transferase) increased in DEN+RSV 50 and DEN+RSV 100 groups compared with control group but decreased in DEN+RSV 50 and DEN+RSV 100 groups compared with DEN group. Bax/Bcl-2 and p53 analysis showed a statistically significant increase in apoptotic cells in DEN+RSV 100 group.

CONCLUSION

A 100 mg/kg dose of RSV may be a promising treatment for HCC.

摘要

目的

白藜芦醇（RSV）是一种天然存在的植物多酚，具有心脏保护、神经保护、免疫调节和抗癌特性，对多种疾病具有生物学效应。本研究旨在探讨不同剂量的RSV对二乙基亚硝胺（DEN）诱导的大鼠肝细胞癌（HCC）的化学预防作用。

材料与方法

将大鼠随机分为六组，每组七只（n = 42）。对照组（第1组）注射生理盐水，第2组注射二甲基亚砜（DMSO），第3组注射DEN，第4组注射DEN和50 mg/kg的RSV（DEN + RSV 50），第5组注射DEN和75 mg/kg的RSV（DEN + RSV 75），第6组注射DEN和100 mg/kg的RSV（DEN + RSV 100）。通过免疫染色分析促凋亡蛋白Bax/抗凋亡蛋白Bcl-2和肿瘤抑制蛋白p53标志物。

结果

DEN + RSV 100组中超氧化物歧化酶、谷胱甘肽和丙二醛浓度无统计学意义，但最接近对照组浓度。肝功能测试表明，与对照组相比，DEN + RSV 50和DEN + RSV 100组的酶活性（丙氨酸转氨酶、天冬氨酸转氨酶、碱性磷酸酶和γ-谷氨酰转移酶）升高，但与DEN组相比，DEN + RSV 50和DEN + RSV 100组的酶活性降低。Bax/Bcl-2和p53分析显示，DEN + RSV 100组中凋亡细胞有统计学意义的增加。

结论

100 mg/kg剂量的RSV可能是治疗HCC的一种有前景的疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5481/7206832/d86e5074443e/IJBMS-23-071-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5481/7206832/fa613bbc098d/IJBMS-23-071-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5481/7206832/8001ab82b495/IJBMS-23-071-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5481/7206832/eae8c4c5262f/IJBMS-23-071-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5481/7206832/12bb770aee0b/IJBMS-23-071-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5481/7206832/d86e5074443e/IJBMS-23-071-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5481/7206832/fa613bbc098d/IJBMS-23-071-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5481/7206832/8001ab82b495/IJBMS-23-071-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5481/7206832/eae8c4c5262f/IJBMS-23-071-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5481/7206832/12bb770aee0b/IJBMS-23-071-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5481/7206832/d86e5074443e/IJBMS-23-071-g005.jpg

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