Magnuson B A, Schiefer H B, Crichlow E C, Bell J M, Olson J P
Department of Veterinary Physiological Sciences, College of Graduate Studies and Research, University of Saskatchewan, Saskatoon, Canada.
Drug Nutr Interact. 1988;5(4):213-26.
The effects of various high-fat diets (20% w/w) containing commercially available fats and oils (butter, corn oil, corn oil margarine, canola oil, canola oil margarine, soybean oil, soybean oil margarine, sunflower oil, sunflower oil margarine) on myocardial contractility and morphology and on plasma lipids were investigated in male Sprague-Dawley rats fed the diets for 16 weeks. Diets containing corn oil caused significantly (P less than or equal to .05) higher plasma total cholesterol levels than diets containing butter. Significant differences were also determined in lipoprotein levels. Plasma triglyceride levels were significantly (P less than or equal to .05) higher with butter than with sunflower oil or sunflower margarine. No significant differences among the groups occurred in blood pressure, heart rate, or myocardial contractility. Histological evaluation revealed that animals fed canola oil had the highest incidence and severity of myocarditis and fibrosis and that the degree of cardiac lipidosis was not correlated to the erucic-acid content of the diet. Myocardial damage was significantly (P less than or equal to .05) negatively correlated with stearic and palmitic acids and positively correlated with oleic acid. The results indicate that diets low in saturated fats may have adverse long-term effects on the heart.
在雄性斯普拉格-道利大鼠中，研究了含有市售油脂（黄油、玉米油、玉米油人造黄油、菜籽油、菜籽油人造黄油、大豆油、大豆油人造黄油、葵花籽油、葵花籽油人造黄油）的各种高脂肪饮食（20%重量/重量）对心肌收缩力、形态以及血浆脂质的影响，这些大鼠喂食这些饮食16周。含玉米油的饮食比含黄油的饮食导致血浆总胆固醇水平显著更高（P小于或等于0.05）。在脂蛋白水平上也确定了显著差异。黄油组的血浆甘油三酯水平比葵花籽油或葵花籽人造黄油组显著更高（P小于或等于0.05）。各组之间在血压、心率或心肌收缩力方面未出现显著差异。组织学评估显示，喂食菜籽油的动物心肌炎和纤维化的发生率和严重程度最高，并且心脏脂肪变性程度与饮食中的芥酸含量无关。心肌损伤与硬脂酸和棕榈酸显著负相关（P小于或等于0.05），与油酸显著正相关。结果表明，饱和脂肪含量低的饮食可能对心脏有不良的长期影响。
