炎症特征与2019冠状病毒病中细胞毒性细胞频率降低相关。
An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019.
作者信息
Bordoni Veronica, Sacchi Alessandra, Cimini Eleonora, Notari Stefania, Grassi Germana, Tartaglia Eleonora, Casetti Rita, Giancola Maria Letizia, Bevilacqua Nazario, Maeurer Markus, Zumla Alimuddin, Locatelli Franco, De Benedetti Fabrizio, Palmieri Fabrizio, Marchioni Luisa, Capobianchi Maria R, D'Offizi Gianpiero, Petrosillo Nicola, Antinori Andrea, Nicastri Emanuele, Ippolito Giuseppe, Agrati Chiara
机构信息
National Institute for Infectious Diseases Lazzaro Spallanzani, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
Immunotherapy Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal.
出版信息
Clin Infect Dis. 2020 Nov 19;71(16):2272-2275. doi: 10.1093/cid/ciaa577.
Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.
2019冠状病毒病患者体内炎症细胞因子和髓系来源抑制细胞的产生增加。这些与表达穿孔素的自然杀伤（NK）细胞和CD3+T细胞呈负相关。我们观察到，与非重症监护病房（ICU）患者相比，ICU患者中表达穿孔素的NK细胞数量较少，这表明免疫细胞毒性分支受损是一种致病机制。
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