更细致地观察疟疾中的中性粒细胞。
A More Granular View of Neutrophils in Malaria.
机构信息
Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical Veterinary & Life Sciences, University of Glasgow, Glasgow, UK; Malawi-Liverpool Wellcome Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi; Department of Paediatrics, College of Medicine, University of Malawi, Blantyre, Malawi.
出版信息
Trends Parasitol. 2020 Jun;36(6):501-503. doi: 10.1016/j.pt.2020.03.003. Epub 2020 Apr 6.
Neutrophils are abundant innate immune cells with crucial roles in immunity and vascular inflammation. Recent evidence indicates that neutrophils have a dual role in malaria, contributing to both pathogenesis and control of Plasmodium. We discuss emerging mechanisms behind these opposing functions and identify key outstanding questions.
中性粒细胞是丰富的先天免疫细胞，在免疫和血管炎症中起着至关重要的作用。最近的证据表明，中性粒细胞在疟疾中具有双重作用，既有助于发病机制，又有助于控制疟原虫。我们讨论了这些相反功能背后的新兴机制，并确定了关键的未解决问题。
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