State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China; College of Mining, Guizhou University, Guiyang 550025, China.
State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Mater Sci Eng C Mater Biol Appl. 2020 Jul;112:110886. doi: 10.1016/j.msec.2020.110886. Epub 2020 Mar 21.
Osteoarthritis, which is characterized by irreversible destruction of articular cartilage and severe inflammation of joint capsule, may be effectively treated via the synergistic therapy of lubrication restoration and local drug intervention. In this study, zwitterionic polymer-grafted mesoporous silica nanoparticles (MSNs@pSBMA) with the property of enhanced lubrication and sustained drug release were successfully synthesized via photopolymerization of 3-[dimethyl-[2-(2-methylprop-2-enoyloxy) ethyl] azaniumyl] propane-1-sulfonate polymer (pSBMA) on the surface of MSNs. The tribiological test showed that the lubrication performance of MSNs@pSBMA was remarkably improved, with a reduction of 80% in friction coefficient compared with MSNs. It was attributed to hydration lubrication mechanism by which a tenacious hydration layer was formed surrounding the N(CH)(CH) and SO headgroups in the pSBMA polyelectrolyte polymer. Additionally, the surface morphology analysis of the tribopairs demonstrated that MSNs@pSBMA were endowed with excellent anti-wear performance. Importantly, the drug release test illustrated that, compared with MSNs, MSNs@pSBMA achieved good sustained drug release behavior. In summary, the MSNs@pSBMA nanoparticles developed herein, as an injectable lubricant with enhanced lubrication and drug delivery, may represent a promising approach for the treatment of osteoarthritis.
骨关节炎的特征是关节软骨不可逆破坏和关节囊严重炎症，可以通过润滑恢复和局部药物干预的协同治疗有效治疗。在这项研究中，通过在 MSNs 表面光聚合 3-[二甲基-[2-（2-甲基丙烯酰氧基）乙基]铵基]丙烷-1-磺酸聚合物（pSBMA），成功合成了具有增强润滑和持续药物释放性能的两性离子聚合物接枝介孔硅纳米粒子（MSNs@pSBMA）。摩擦生物学试验表明，MSNs@pSBMA 的润滑性能显著提高，与 MSNs 相比，摩擦系数降低了 80%。这归因于 pSBMA 聚电解质聚合物中 N(CH)(CH)和 SO 头基周围形成坚韧的水合层的水合润滑机制。此外，摩擦副的表面形貌分析表明，MSNs@pSBMA 具有优异的抗磨性能。重要的是，药物释放试验表明，与 MSNs 相比，MSNs@pSBMA 实现了良好的持续药物释放行为。总之，本文开发的 MSNs@pSBMA 纳米粒子作为一种具有增强润滑和药物输送功能的可注射润滑剂，可能为骨关节炎的治疗提供一种有前途的方法。
