Sun Tao, Sun Yulong, Zhang Hongyu
State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.
Polymers (Basel). 2018 May 9;10(5):513. doi: 10.3390/polym10050513.
Osteoarthritis (OA) is a severe disease caused by wear and inflammation of joints. In this study, phospholipid-coated mesoporous silica nanoparticles (MSNs@lip) were prepared in order to treat OA at an early stage. The phospholipid layer has excellent lubrication capability in aqueous media due to the hydration lubrication mechanism, while mesoporous silica nanoparticles (MSNs) act as effective drug nanocarriers. The MSNs@lip were characterized by scanning electron microscope, transmission electron microscope, Fourier transform infrared spectrum, X-ray photoelectron spectrum, thermogravimetric analysis and dynamic light scattering techniques to confirm that the phospholipid layer was coated onto the surface of MSNs successfully. A series of tribological tests were performed under different experimental conditions, and the results showed that MSNs@lip with multi-layers of phospholipids greatly reduced the friction coefficient in comparison with MSNs. Additionally, MSNs@lip demonstrated sustained drug release behavior and were biocompatible based on CCK-8 assay using MC3T3-E1 cells. The MSNs@lip developed in the present study, acting as effective lubricating drug nanocarriers, may represent a promising strategy to treat early stage OA by lubrication enhancement and drug delivery therapy.
骨关节炎（OA）是一种由关节磨损和炎症引起的严重疾病。在本研究中，制备了磷脂包覆的介孔二氧化硅纳米颗粒（MSNs@lip）以在早期治疗OA。由于水化润滑机制，磷脂层在水性介质中具有优异的润滑能力，而介孔二氧化硅纳米颗粒（MSNs）作为有效的药物纳米载体。通过扫描电子显微镜、透射电子显微镜、傅里叶变换红外光谱、X射线光电子能谱、热重分析和动态光散射技术对MSNs@lip进行表征，以确认磷脂层成功包覆在MSNs表面。在不同实验条件下进行了一系列摩擦学测试，结果表明，与MSNs相比，多层磷脂的MSNs@lip大大降低了摩擦系数。此外，基于使用MC3T3-E1细胞的CCK-8测定，MSNs@lip表现出持续的药物释放行为且具有生物相容性。本研究中开发的MSNs@lip作为有效的润滑药物纳米载体，可能代表了一种通过增强润滑和药物递送疗法治疗早期OA的有前景的策略。
