Ravdonikas L E, Rýc M, Grabovskaya K B, Totolian A A
Institute of Experimental Medicine, Academy of Medical Sciences, Prague, Czechoslovakia.
Folia Microbiol (Praha). 1988;33(6):513-9. doi: 10.1007/BF02925779.
Adherence of three strains of group A streptococci and their fosfomycin-resistant mutants to HEp-2 tissue culture cells was compared with some cell-surface characteristics, i.e. ultrastructure and hydrophobicity. Among Fosr mutants, both well-adhering and weakly adhering mutants were found. Clonal analysis of the mutants proved their greater stability in the adherence. Well-adhering parent strains of streptococci and Fosr mutants exhibited surface fibrillae in contrast to weakly adhering Fosr mutants which were devoid of fibrillae or contined fibrillae of lower electron density. Decrease of adherence of Fosr mutants of two strains was accompanied by a decrease of their hydrophobicity.
将三株A组链球菌及其磷霉素抗性突变体对HEp-2组织培养细胞的黏附情况与一些细胞表面特征，即超微结构和疏水性进行了比较。在磷霉素抗性突变体中，发现了黏附性良好和黏附性较弱的突变体。对这些突变体的克隆分析证明了它们在黏附方面具有更高的稳定性。与缺乏纤毛或纤毛电子密度较低的弱黏附性磷霉素抗性突变体相比，黏附性良好的链球菌亲本菌株和磷霉素抗性突变体表现出表面纤毛。两株菌株的磷霉素抗性突变体黏附性降低伴随着其疏水性的降低。
