Ravdonikas L E, Grabovskaya K B, Totolian A A
Institute of Experimental Medicine, Academy of Science of USSR, Leningrad.
Folia Microbiol (Praha). 1988;33(6):507-12. doi: 10.1007/BF02925778.
Eighty-nine fosfomycin-resistant mutants of group A and B streptococci were isolated. The mutants differed essentially from the parent strains in cell-wall characteristics, such as morphology of cocci and chains, sensitivity to detergents and hydrophobic properties. At the same time, the recipient activity of the investigated mutants was not changed. It is supposed that resistance of mutants to fosfomycin is connected with a transport block of glycerol 3-phosphate--important lipoteichoic acid (LTA) structural component. Fosr mutants can be useful for experimental examination of Beachey's hypothesis about the importance of LTA or its complex with the M protein for adhesion.
分离出了89株A组和B组链球菌的磷霉素抗性突变体。这些突变体在细胞壁特征方面与亲本菌株存在本质差异，如球菌和菌链的形态、对去污剂的敏感性和疏水特性。同时，所研究突变体的受体活性未发生改变。推测突变体对磷霉素的抗性与甘油3 - 磷酸（重要的脂磷壁酸（LTA）结构成分）的转运受阻有关。Fosr突变体可用于对Beachey关于LTA或其与M蛋白复合物对黏附重要性的假说进行实验验证。
