微环 DNA：基于 DNA 的载体的未来？
Minicircle DNA: The Future for DNA-Based Vectors?
机构信息
CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.
CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.
出版信息
Trends Biotechnol. 2020 Oct;38(10):1047-1051. doi: 10.1016/j.tibtech.2020.04.008. Epub 2020 May 11.
Minicircle DNA (mcDNA) is a smaller and safer version of non-viral DNA vectors that results from a cutting-edge in vivo recombination process to excise prokaryotic sequences from plasmid DNA (pDNA). Considering the molecule's potential and increasing interest as a non-viral DNA-based therapeutic, biomanufacturing methodologies need to be improved, especially in downstream processing.
微环 DNA (mcDNA) 是一种更小、更安全的非病毒 DNA 载体，它是通过一种前沿的体内重组过程从质粒 DNA (pDNA) 中切除原核序列而产生的。考虑到该分子的潜力和作为非病毒 DNA 治疗方法的兴趣日益增加，需要改进生物制造方法，特别是在下游处理中。
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