Singh Vivek, Ubaid Saba
Department of Biochemistry, King George's Medical University (KGMU), Lucknow, U.P., 226003, India.
Inflammation. 2020 Oct;43(5):1589-1598. doi: 10.1007/s10753-020-01242-9.
Silent information regulator 1 (SIRT1) is a ubiquitously expressed protein and has an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a NAD+-dependent deacetylase and regulates gene expression by histone deacetylation. Deletion of SIRT1 in the liver, pancreas, and brain significantly increases the reactive oxygen species (ROS) and inflammatory response. Literature survey on SIRT1 shows the evidence for its role in preventing oxidative stress and inflammation. Oxidative stress and inflammation are closely related pathophysiological processes and are involved in the pathogenesis of a number of chronic disorders such as fatty liver diseases, diabetes, and neurodegenerative diseases. Both oxidative stress and inflammation alter the expression of several genes such as nuclear factor E2 related factor (Nrf2), nuclear factor E2 related factor 2 (Nef2), nuclear factor kappa B (NF-kB), pancreatic and duodenal homeobox factor 1 (PDX1), interleukin-1 (IL1), forkhead box class O (FOXO), and tumour necrosis factor alpha (TNF-α). By annotating this knowledge, we can conclude that modulating the expression of SIRT1 might prevent the onset of diseases inexorably linked to the liver, pancreas, and brain. Graphical Abstract Role of silent information regulator 1 (SIRT1) in the pancreas, brain, and liver.
沉默信息调节因子1（SIRT1）是一种广泛表达的蛋白质，在多种疾病的病理、进展和治疗中发挥着复杂的作用。SIRT1是一种烟酰胺腺嘌呤二核苷酸（NAD+）依赖性脱乙酰酶，通过组蛋白去乙酰化调节基因表达。在肝脏、胰腺和大脑中缺失SIRT1会显著增加活性氧（ROS）和炎症反应。关于SIRT1的文献调查显示了其在预防氧化应激和炎症方面作用的证据。氧化应激和炎症是密切相关的病理生理过程，参与了许多慢性疾病如脂肪肝疾病、糖尿病和神经退行性疾病的发病机制。氧化应激和炎症都会改变多种基因的表达，如核因子E2相关因子（Nrf2）、核因子E2相关因子2（Nef2）、核因子κB（NF-κB）、胰腺和十二指肠同源盒因子1（PDX1）、白细胞介素-1（IL1）、叉头框O类（FOXO）和肿瘤坏死因子α（TNF-α）。通过整理这些知识，我们可以得出结论，调节SIRT1的表达可能预防与肝脏、胰腺和大脑密切相关的疾病的发生。图形摘要 沉默信息调节因子1（SIRT1）在胰腺、大脑和肝脏中的作用。
