抗真菌评价传统草药单体及其在 和 中诱导细胞壁重塑的潜力。
Antifungal evaluation of traditional herbal monomers and their potential for inducing cell wall remodeling in and .
机构信息
Laboratory of Infection and Immunology, College of Integrated Chinese and Western Medicine (College of Life Science), Anhui University of Chinese Medicine, Hefei, Anhui, PR China.
Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei, Anhui, PR China.
出版信息
Biofouling. 2020 Mar;36(3):319-331. doi: 10.1080/08927014.2020.1759559. Epub 2020 May 15.
Traditional herbal monomers (THMs) are widely distributed in many traditional Chinese formulas (TCFs) and decoctions (TCDs) and are frequently used for the prevention and treatment of fungal infections. The antifungal activities of five common THMs, including sodium houttuyfonate (SH), berberine (BER), palmatine (PAL), jatrorrhizine (JAT) and cinnamaldehyde (CIN), and their potential for inducing cell wall remodeling (CWR), were evaluated against SC5314 and 12372. SH/CIN plus BER/PAL/JAT showed synergistic antifungal activity against both isolates. Furthermore, SH-associated combinations (SH plus BER/PAL/JAT) induced stronger exposure of β-glucan and chitin than their counterparts, while CIN triggered more marked exposure compared with CIN-associated combinations (CIN plus BER/PAL/JAT). Collectively, this study demonstrated the anti- effect and the CWR induction potential of the five THMs and their associated combinations, providing a possibility of their application against fungal-associated infections.
传统草药单体（THMs）广泛分布于许多中药方剂（TCFs）和煎剂（TCDs）中，常用于预防和治疗真菌感染。本研究评估了 5 种常见 THMs（包括 Sodium houttuyfonate [SH]、Berberine [BER]、Palmatine [PAL]、Jatrorrhizine [JAT]和 Cinnamaldehyde [CIN]）及其诱导细胞壁重塑（CWR）的能力，以评估其对 SC5314 和 12372 的抗真菌活性。SH/CIN 加 BER/PAL/JAT 对两种分离株均表现出协同抗真菌活性。此外，与对照相比，与 SH 相关的组合（SH 加 BER/PAL/JAT）诱导β-葡聚糖和几丁质的暴露更强，而 CIN 诱导的暴露比 CIN 相关的组合（CIN 加 BER/PAL/JAT）更明显。总之，本研究表明了这 5 种 THMs 及其相关组合的抗真菌作用和 CWR 诱导潜力，为其在真菌相关感染中的应用提供了可能。
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