Herman Anna, Herman Andrzej Przemysław
Faculty of Health Sciences, Warsaw School of Engineering and Health, Bitwy Warszawskiej 1920 18 Street, 02-366 Warsaw, Poland.
Department of Genetic Engineering, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 Street, 05-110 Jabłonna, Poland.
Antibiotics (Basel). 2021 May 31;10(6):655. doi: 10.3390/antibiotics10060655.
Clinical isolates of yeast are the most common cause of opportunistic fungal infections resistant to certain antifungal drugs. Therefore, it is necessary to detect more effective antifungal agents that would be successful in overcoming such infections. Among them are some herbal products and their active constituents.The purpose of this review is to summarize the current state of knowledge onherbal products and their active constituents havingantifungal activity against drug-resistant sp. used alone and in combination with antifungal drugs.The possible mechanisms of their action on drug-resistant sp. including (1) inhibition of budding yeast transformation into hyphae; (2) inhibition of biofilm formation; (3) inhibition of cell wall or cytoplasmic membrane biosynthesis; (4) ROS production; and (5) over-expression of membrane transporters will be also described.
酵母临床分离株是对某些抗真菌药物耐药的机会性真菌感染的最常见原因。因此，有必要检测出能成功克服此类感染的更有效的抗真菌药物。其中包括一些草药产品及其活性成分。本综述的目的是总结关于对耐药性酵母有抗真菌活性的草药产品及其活性成分的现有知识状态，这些草药产品及其活性成分单独使用以及与抗真菌药物联合使用的情况。还将描述它们对耐药性酵母的可能作用机制，包括：（1）抑制出芽酵母向菌丝的转变；（2）抑制生物膜形成；（3）抑制细胞壁或细胞质膜生物合成；（4）活性氧的产生；以及（5）膜转运蛋白的过度表达。
