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对抗新型超级细菌的有前景的候选药物和新策略

Promising Drug Candidates and New Strategies for Fighting against the Emerging Superbug .

作者信息

Billamboz Muriel, Fatima Zeeshan, Hameed Saif, Jawhara Samir

机构信息

Inserm, CHU Lille, Institut Pasteur Lille, Université Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement, F-59000 Lille, France.

Junia, Health and Environment, Laboratory of Sustainable Chemistry and Health, F-59000 Lille, France.

出版信息

Microorganisms. 2021 Mar 18;9(3):634. doi: 10.3390/microorganisms9030634.

DOI:10.3390/microorganisms9030634
PMID:33803604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8003017/
Abstract

Invasive fungal infections represent an expanding threat to public health. During the past decade, a paradigm shift of candidiasis from to non-albicans species has fundamentally increased with the advent of . was identified in 2009 and is now recognized as an emerging species of concern and underscores the urgent need for novel drug development strategies. In this review, we discuss the genomic epidemiology and the main virulence factors of . We also focus on the different new strategies and results obtained during the past decade in the field of antifungal design against this emerging pathogen yeast, based on a medicinal chemist point of view. Critical analyses of chemical features and physicochemical descriptors will be carried out along with the description of reported strategies.

摘要

侵袭性真菌感染对公共卫生构成了日益严重的威胁。在过去十年中，随着[具体情况未提及]的出现，念珠菌病从[具体情况未提及]向非白色念珠菌物种的范式转变显著增加。[具体物种未提及]于2009年被发现，现在被认为是一个值得关注的新兴物种，凸显了对新型药物开发策略的迫切需求。在这篇综述中，我们讨论了[具体物种未提及]的基因组流行病学和主要毒力因子。我们还从药物化学家的角度，重点关注了过去十年在针对这种新兴的[具体物种未提及]病原体酵母的抗真菌设计领域中获得的不同新策略和结果。将在对已报道策略进行描述的同时，对化学特征和物理化学描述符进行批判性分析。

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